Influence of Stress and Depression on the Immune System in Patients Evaluated in an Anti-aging Unit
Influence of Stress and Depression on the Immune System in Patients Evaluated in an Anti-aging Unit
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DOI：
10.3389/fpsyg.2020.01844
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发表时间：
2020-08-04
影响因子：
3.8
通讯作者：
Martinez-Fernandez, Vicente
中科院分区：
文献类型：
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作者：
Canas-Gonzalez, Beatriz;Fernandez-Nistal, Alonso;Martinez-Fernandez, Vicente
背景有令人信服的证据指出，压力和抑郁症对人类健康产生巨大影响，主要是通过损害免疫系统的正常功能，产生有利于感染、代谢疾病甚至癌症发生的低慢性炎症状态。目前的工作旨在评估的压力/抑郁水平的抗衰老单位治疗的一些患者，并检测任何潜在的关系，他们的免疫系统状态之前，实施的身体/心理计划，旨在防止健康恶化。方法从心理学和免疫学的角度对48例中上层社会阶层患者进行评估。特别是，我们分析了中性粒细胞的趋化性和吞噬作用，淋巴细胞的趋化性和增殖，自然杀伤（NK）细胞的活性。结果女性抑郁症状明显多于男性。女性的淋巴细胞和中性粒细胞的趋化性水平与男性相比显着降低。我们还发现抑郁症和NK细胞功能之间存在很强的负相关性。这种相关性也与性别无关。结论NK活性至少受抑郁状态的影响，我们建议认知行为疗法和体力活动计划组成的联合治疗可能会改善患者的健康恶化。
Background There is compelling evidence pointing out that stress and depression produce a dramatic impact on human well-being mainly through impairing the regular function of the immune system and producing a low-chronic inflammation status that favors the occurrence of infections, metabolic diseases, and even cancer. The present work aims to evaluate the stress/depression levels of some patients treated in an antiaging unit and detect any potential relationship with their immune system status prior of the implementation of a physical/psychological program designed to prevent health deterioration. Methods We evaluated 48 patients (16 men and 32 women with a mean age of 55.11 +/- 10.71 years) from middle-upper class from psychological and immunological points of view. In particular, we analyzed neutrophil chemotaxis and phagocytosis; lymphocyte chemotaxis and proliferation, and natural killer (NK) cell activity. Results Women showed more depressive symptoms than men. Chemotaxis levels of lymphocytes and neutrophils in women showed a significant reduction compared with those in men. We also found a strong negative correlation between depression and NK cell function. This correlation was also significant independently of gender. Conclusion We conclude that NK activity is affected at least by depression state, and we propose that a combined treatment consisting of cognitive behavioral therapy and physical activity programs might improve patient health deterioration.