Involvement of sigma (σ1) receptors in modulating the anti-depressant effect of neurosteroids (dehydroepiandrosterone or pregnenolone) in mouse tail-suspension test
Involvement of sigma (σ1) receptors in modulating the anti-depressant effect of neurosteroids (dehydroepiandrosterone or pregnenolone) in mouse tail-suspension test
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DOI：
10.1177/0269881107082771
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发表时间：
2008-08-01
影响因子：
4.1
通讯作者：
Kulkarni, S. K.
中科院分区：
文献类型：
--
作者：
Dhir, A.;Kulkarni, S. K.
本研究探讨了神经甾体硫酸脱氢表雄酮（DHEAS）或硫酸双烯醇酮（PS）对小鼠抑郁悬尾试验（TST）的影响，以及sigma（sigma）受体的可能参与。测量TST中的不动时间，总共6分钟。DHEAS（10和40 mg/kg，皮下注射）或PS（40mg/kg，s.c.）显著减少小鼠的不动期，而不伴随运动活动的变化。DHEAS（10和40 mg/kg，s.c.）和PS（40mg/kg，s.c.）BD 1047（1mg/kg，s.c.）一种新的σ（1）-受体拮抗剂孕酮（10 mg/kg，s.c.），σ-受体拮抗性神经类固醇或瑞姆卡唑（5 mg/kg，s.c.），另一种σ（1）-受体拮抗特性。治疗及其组合并没有改变小鼠的运动活动。这些数据表明，中央σ受体，特别是σ-1（σ（1））受体在神经类固醇的抗神经胶质瘤样作用中的作用。
The present study investigated the effects of neurosteroids dehydroepiandrosterone sulfate (DHEAS) or pregnenolone sulfate (PS) on the tail-suspension test (TST) of depression in mice, and also the possible involvement of sigma (sigma) receptors. Immobility time in the TST was measured for a total period of 6 min. DHEAS (10 and 40mg/kg, s.c.) or PS (40mg/kg, s.c.) significantly reduced the immobility period without accompanying changes in the locomotor activity in mice. The effect on behavioural despair by DHEAS (10 and 40mg/kg, s.c.) and PS (40mg/kg, s.c.) was blocked by BD 1047 (1mg/kg, s.c.), a novel sigma(1)-receptor antagonist, progesterone (10mg/kg, s.c.), a sigma-receptor antagonistic neurosteroid or rimcazole (5mg/kg, s.c.), another sigma(1)-receptor antagonistic property, respectively. The treatments and their combination did not alter the motor activity in mice. These data suggested a role for the central sigma receptors particularly sigma-1 (sigma(1)) receptors in the anti-depressant-like effects of neurosteroids.