Cumulative blood oxygenation-level-dependent signal changes support the 'time accumulator' hypothesis
Cumulative blood oxygenation-level-dependent signal changes support the 'time accumulator' hypothesis
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DOI：
10.1097/01.wnr.0000175616.00936.1c
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发表时间：
2005-09-08
期刊：
影响因子：
1.7
通讯作者：
Vymazal, J
中科院分区：
文献类型：
--
作者：
Jech, R;Dusek, P;Vymazal, J
我们研究了时间再现任务中血氧水平依赖信号的时间相关变化。9名健康的研究参与者保留并再现了多秒范围内不同持续时间的刺激。在编码阶段，左背外侧前额叶皮层的活动与间隔时间呈负相关，而背外侧前额叶皮层的相邻区域与再现阶段的时间呈正相关。生殖阶段累积的信号增加，如在主要运动区和辅助运动区发现的那样，也可能反映了时间敏感的行为。右侧尾状核中的信号积累与基底神经节在时间知觉中的假定作用一致。这些结果支持“时间累积器”假说。
We studied time-related changes in the blood oxygenation-level-dependent signal during a time reproduction task. Nine healthy study participants retained and reproduced stimuli of varying durations in the multi-second range. During the encoding phase of the task, activity in the left dorsolateral prefrontal cortex inversely correlated with the interval duration, while an adjacent region in the dorsolateral prefrontal cortex showed positive correlation with duration in the reproduction phase. Cumulative signal increase during the reproduction phase, as found in the primary motor and supplementary motor areas, may also reflect the time-sensitive behavior. Signal accumulation in the right caudate nucleus is in agreement with presumed role of basal ganglia in time perception. These results support the 'time accumulator' hypothesis.