fMRI activation in relation to sound intensity and loudness
fMRI activation in relation to sound intensity and loudness
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DOI：
10.1016/j.neuroimage.2006.12.013
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发表时间：
2007-04-01
期刊：
影响因子：
5.7
通讯作者：
Backes, Walter H.
中科院分区：
文献类型：
--
作者：
Langers, Dave R. M.;van Dijk, Pirn;Backes, Walter H.
这项功能磁共振成像研究的目的是将皮质功能磁共振成像反应与物理和感知声级特征联系起来。除听力正常的受试者外，还包括高频感音神经性听力损失的受试者，因为响度感知失真是高频感音神经性听力损失的特征。两组受试者的皮质反应被分析为低频率和高频刺激的物理强度和感知响度的函数。低频刺激强度范围为0 ~ 70 dB SL；对于高频刺激，设置了强度水平，使相应的响度水平与低频刺激相匹配。结果表明，反应随强度和响度的增加呈显著线性增加。在最高水平的响应饱和不明显，但激活表现出在0和10分贝之间的低频刺激急剧上升。听力损失受试者的激活随刺激强度的增加明显强于听力正常受试者。这反映了响度招募，其特征是响度随刺激强度不成比例地增加。相比之下，两个被试组之间的激活率增加作为响度水平的函数没有差异。这表明听觉皮层的fMRI激活与对刺激的感知（即响度）而不是其物理特征（即强度）更密切相关。(c) 2006爱思唯尔公司版权所有。
The aim of this fMRI study was to relate cortical fMRI responses to both physical and perceptual sound level characteristics. Besides subjects with normal hearing, subjects with high-frequency sensorineural hearing loss were included, as distortion of loudness perception is a characteristic of such impairment. Cortical responses in both subject groups were analyzed as a function of the physical intensity and the perceived loudness of low and high-frequency stimuli. For the low-frequency stimuli, intensity levels ranged from 0 to 70 dB SL; for the high-frequency stimuli, intensity levels were set such that the corresponding loudness levels matched those of the low-frequency stimuli. Responses were found to increase significantly and predominantly linearly with intensity level and with loudness level. Response saturation at the highest levels was not apparent, but activation exhibited a steep rise between 0 and 10 dB for the low-frequency stimuli. The activation in the subjects with hearing loss increased significantly more strongly with stimulus intensity than that in the normally hearing subjects. This reflects loudness recruitment, characterized by a disproportionate increase in loudness with stimulus intensity. In contrast, the rate of activation increase as a function of loudness level did not differ between both subject groups. This demonstrates that fMRI activation at the level of the auditory cortex is more closely related to the percept of a stimulus (i.e., loudness) rather than to its physical characteristics (i.e., intensity). (c) 2006 Elsevier Inc. All rights reserved.