EFFECTS OF ULTRASOUND BEAM ANGLE AND SURFACE ROUGHNESS ON THE QUANTITATIVE ULTRASOUND PARAMETERS OF ARTICULAR CARTILAGE
EFFECTS OF ULTRASOUND BEAM ANGLE AND SURFACE ROUGHNESS ON THE QUANTITATIVE ULTRASOUND PARAMETERS OF ARTICULAR CARTILAGE
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DOI：
10.1016/j.ultrasmedbio.2009.03.009
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发表时间：
2009-08-01
影响因子：
2.9
通讯作者：
Toyras, J.
中科院分区：
文献类型：
--
作者：
Kaleva, E.;Saarakkala, S.;Toyras, J.
高分辨率关节镜超声成像为早期骨关节炎的诊断提供了一种潜在的定量技术。然而，超声波束的不受控制的非垂直角度或软骨表面的自然曲率可能会危及超声测量的可靠性。我们系统地评价了关节面倾斜对定量超声参数的影响。使用50-MHz扫描声学系统对视觉上完整（n = 8）和机械降解（n = 6）的骨软骨化牛髌骨样本以及自发原纤化（n = 1）和自发蛋白聚糖耗尽（n = 1）的骨软骨化人胫骨样本进行成像。将每个样品的表面调节到预定的倾斜角度（0、2、5和7度），并分析沿着倾斜方向的五条超声扫描线。计算每条扫描线的反射系数（R）、积分反射系数（IRC）和超声粗糙度指数（URI）。软骨表面粗糙度对R、IRC和URI有显著影响（p < 0.05）。重要的是，所有超声参数都能够区分（p < 0.05）机械降解样品与完整样品，即使样品中超声波束的入射角在0和5度之间变化。在诊断上，目前的发现是重要的，因为关节表面的自然曲率是变化的，并且在临床测量中实现超声波束和软骨表面之间的完美的对称性可能是具有挑战性的。（电子邮件：erna. uku.fi）（C）2009年世界医学和生物学超声联合会。
High-resolution arthroscopic ultrasound imaging provides a potential quantitative technique for the diagnostics of early osteoarthritis. However, an uncontrolled, nonperpendicular angle of an ultrasound beam or the natural curvature of the cartilage surface may jeopardize the reliability of the ultrasound measurements. We evaluated systematically the effect of inclining an articular surface on the quantitative ultrasound parameters. Visually intact (n = 8) and mechanically degraded (n = 6) osteochondral bovine patella samples and spontaneously fibrillated (n = 1) and spontaneously proteoglycan depleted (n = 1) osteochondral human tibial samples were imaged using a 50-MHz scanning acoustic system. The surface of each sample was adjusted to predetermined inclination angles (0, 2, 5 and 7 degrees) and five ultrasound scan lines along the direction of the inclination were analyzed. For each scan line, reflection coefficient (R), integrated reflection coefficient (IRC) and ultrasound roughness index (URI) were calculated. Nonperpendicularity of the cartilage surface was found to affect R, IRC and URI significantly (p < 0.05). Importantly, all ultrasound parameters were able to distinguish (p < 0.05) the mechanically degraded samples from the intact ones even though the angle of incidence of the ultrasound beam varied between 0 and 5 degrees among the samples. Diagnostically, the present findings are important because the natural curvature of the articular surface varies, and a perfect perpendicularity between the ultrasound beam and the surface of the cartilage may be challenging to achieve in a clinical measurement. (E-mail: erna.kaleva@uku.fi) (C) 2009 World Federation for Ultrasound in Medicine & Biology.