Familial aggregation of eye-tracking endophenotypes in families of schizophrenic patients
Familial aggregation of eye-tracking endophenotypes in families of schizophrenic patients
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DOI：
10.1001/archpsyc.63.3.259
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发表时间：
2006-03-01
影响因子：
--
通讯作者：
Thaker, GK
中科院分区：
文献类型：
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作者：
Hong, LE;Mitchell, BD;Thaker, GK
背景：异常平稳追踪眼球运动(SPEM)是与精神分裂症易感性相关的一些最具重复性的生物学变化。最近的研究表明，预测追踪缺陷是SPEM的一个特定成分，它标志着精神分裂症的易感性。目的：检验预测追踪是否包含更少的外部噪声，是否比使用维持追踪增益的传统总体追求绩效测量更受基因控制。设计：对来自精神分裂症患者家庭的兄弟姐妹对预测追踪测量和传统维持追踪测量进行家庭聚合估计。地点：门诊。参与者：精神分裂症患者及其全部兄弟姐妹被招募，前提是每个家庭至少形成一对兄弟姐妹。92个兄弟姐妹被招募到这项研究中。他们结成了70对兄弟姐妹。90名健康对照受试者也通过以患者居住地为基础的有针对性的当地社区广告招募，旨在获取患者所在地区的基本人口学数据。主要观察指标：维持追求收益和预测追求收益两种SPEM测量的家族相关性和遗传度估计。结果：预测追求收益的兄弟姐妹组内相关系数(r=0.45~0.48)显著高于维持追求收益(r=0.02~0.20)(P=0.005~0.007)。方差分析显示预测追踪的遗传力较高(遗传力=0.90，SE=0.22；P
Background: Abnormal smooth pursuit eye movements (SPEMs) are some of the most reproducible biological changes associated with the susceptibility for schizophrenia. Recent studies have suggested that deficit in predictive pursuit, a specific component of the SPEMs, marks schizophrenia susceptibility.Objective: To test whether predictive pursuit contains less extraneous noise and may be under more direct genetic control than the traditional measure of overall pursuit performance using maintenance pursuit gain.Design: Familial aggregation estimation of the predictive pursuit measure and the traditional maintenance pursuit measure in sibling pairs from families of schizophrenic patients.Setting: Outpatient clinics.Participants: Patients with schizophrenia and their full siblings were recruited, provided that at least 1 sibling pair could be formed per family. Ninety-two siblings were recruited into the study. They formed 70 sibling pairs. Ninety healthy control subjects were also recruited using targeted local community advertisements based on patients' county of residence, aiming to capture the basic demographics of the regions from which the patients were recruited.Main Outcome Measures: Familial correlations and heritability estimates of 2 SPEM measures: maintenance pursuit gain and predictive pursuit gain.Results: The sibling intraclass correlation coefficient of the predictive pursuit gain (r=0.45-0.48) was significantly higher than that of maintenance pursuit gain (r=0.02-0.20) (P=.005-.007). Variance component analysis suggested a high genetic loading for predictive pursuit (heritability=0.90, SE= 0.22; P