The ezrin-radixin-moesin family of proteins in the regulation of B-cell immune response.
The ezrin-radixin-moesin family of proteins in the regulation of B-cell immune response.
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DOI：
10.1615/critrevimmunol.2015012327
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发表时间：
2015
影响因子：
1.3
通讯作者：
Gupta N
中科院分区：
文献类型：
--
作者：
Pore D;Gupta N
皮质细胞骨架的动态重组在许多细胞过程中是必不可少的，包括B和T细胞的激活和迁移。Ezrin、Radixin和Moesin(ERM)家族蛋白通过与皮质肌动蛋白细丝和质膜的可逆相互作用，在质膜柔韧性和突起的重排中发挥结构和调节作用。最近的研究表明，ERM蛋白不仅参与细胞骨架的组织，而且通过其将跨膜受体与下游信号成分交联的能力，为响应各种细胞外刺激的信号传递提供了一个平台。在这篇综述中，我们总结了目前的知识和最近的进展，以阐明ERM蛋白在调节B功能的健康和疾病中的新作用。
Dynamic reorganization of the cortical cytoskeleton is essential for numerous cellular processes including B and T cell activation and migration. The Ezrin, Radixin and Moesin (ERM) family proteins play structural and regulatory roles in the rearrangement of plasma membrane flexibility and protrusions through their reversible interaction with cortical actin filaments and plasma membrane. Recent studies demonstrate that ERM proteins are not only involved in cytoskeletal organization but also offer a platform for the transmission of signals in response to a variety of extracellular stimuli through their ability to crosslink transmembrane receptors with downstream signaling components. In this review, we summarize the present knowledge and recent progress made towards elucidating a novel role of ERM proteins in the regulation of B function in health and disease.