Distributions of diffuse intimal thickening in human arteries: preferential expression in atherosclerosis-prone arteries from an early age
Distributions of diffuse intimal thickening in human arteries: preferential expression in atherosclerosis-prone arteries from an early age
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DOI：
10.1007/s00428-002-0605-1
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发表时间：
2002-09-01
期刊：
影响因子：
3.5
通讯作者：
Sueishi, K
中科院分区：
文献类型：
--
作者：
Nakashima, Y;Chen, YX;Sueishi, K
弥漫性内膜增厚（Diffuse intimal thickening，DIT）是动脉粥样硬化形成前存在于人动脉中的增厚的内膜，被认为与动脉粥样硬化形成有关。本研究的目的是阐明DIT的系统和年龄分布。对72例尸检病例（年龄36周至30岁）的冠状动脉、脑动脉、颈动脉、锁骨下动脉、髂动脉、腹动脉和主动脉进行了检查。DIT分别在妊娠36周和出生后第一年的冠状动脉和主动脉中发现。冠状动脉的内膜/中膜（I/M）比值显示出随年龄增长的增加，并且远大于其他肌性动脉，即，颅内和脑实质外动脉和腹部器官动脉。主动脉也表现出年龄依赖性以及部位依赖性的I/M比增加;节段越远，比值越大。因此，腹主动脉在主动脉内具有最大的I/M比。其他弹性动脉，即，颈动脉、锁骨下动脉和髂动脉显示出与主动脉远端部分相似的趋势。因此，DIT在被认为易于发生动脉粥样硬化的动脉中从早期就强烈表达。这些发现表明动脉粥样硬化的发展至少部分取决于DIT的程度。
Diffuse intimal thickening (DIT) is a thickened intima present in human arteries before atherosclerosis develops and is considered to be related to atherogenesis. The purpose of this study was to clarify the systemic and age distributions of DIT. Coronary, cerebral, carotid, subclavian, iliac and abdominal organ arteries and the aorta were examined in 72 autopsy cases (aged 36 weeks of gestation to 30 years at death). DIT was found in the coronary arteries and aorta from 36 weeks of gestation and the first year of life, respectively. The intima/media (I/M) ratio of coronary arteries showed an age-dependent increase and was much greater than that of other muscular arteries, i.e., intracranial and extraparenchymal cerebral arteries and abdominal organ arteries. Aorta also demonstrated age-dependent as well as site-dependent increases of I/M ratio; the more distal the segments, the greater the ratio. Consequently, the abdominal aorta had the largest I/M ratio within the aorta. Other elastic arteries, i.e., carotid, subclavian and iliac arteries, showed trends similar to the distal portions of the aorta. Thus, DIT was strongly expressed from an early age in arteries that are considered to be prone to atherosclerosis. These findings suggest that the development of atherosclerosis depends at least partly on the degree of DIT.