Minimal Clinically Important Differences of Disease Activity Indices in Childhood-Onset Systemic Lupus Erythematosus
Minimal Clinically Important Differences of Disease Activity Indices in Childhood-Onset Systemic Lupus Erythematosus
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DOI：
10.1002/acr.20154
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发表时间：
2010-07-01
影响因子：
4.7
通讯作者：
Giannini, Edward H.
中科院分区：
文献类型：
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作者：
Brunner, Hermine I.;Higgins, Gloria C.;Giannini, Edward H.
Objective.确定儿童期发病的系统性红斑狼疮（SLE）疾病活动性的经验证测量值的最小临床重要差异（MCID）。方法。儿童期SLE患者（n = 98）每3个月随访一次，最多7次访视（n = 623次总访视）。在每次访视时完成疾病活动性测量（欧洲共识狼疮活动性测量、系统性红斑狼疮疾病活动性指数、系统性狼疮活动性测量、不列颠群岛狼疮评估组和红斑狼疮应答者指数[步枪]）。两次访视之间医生评定的病程变化（临床相关改善、无变化、临床相关恶化）作为标准。MCID定义为改善和恶化的平均变化分数，或基于疾病稳定测量的标准误差，两者都很小，并且不能很好地区分疾病过程（改善或恶化的检出率均为10%）。
Objective. To determine the minimal clinically important differences (MCIDs) of validated measures of systemic lupus erythematosus (SLE) disease activity in childhood-onset SLE.Methods. Childhood-onset SLE patients (n = 98) were followed every 3 months for up to 7 visits (n = 623 total visits). Disease activity measures (European Consensus Lupus Activity Measure, Systemic Lupus Erythematosus Disease Activity Index, Systemic Lupus Activity Measure, British Isles Lupus Assessment Group, and Responder Index for Lupus Erythematosus [ RIFLE]) were completed at the time of each visit. Physician-rated changes in the disease course (clinically relevant improvement, no change, clinically relevant worsening) between visits served as the criterion standard.Results. MCIDs defined by mean change scores with improvement and worsening, or those based on the standard error of measurement with stable disease, were both small and did not discriminate well between disease courses (detection rates for improvement or worsening were all