Myasthenia gravis with membranous nephropathy, successfully treated with extended total thymectomy.
Myasthenia gravis with membranous nephropathy, successfully treated with extended total thymectomy.
复制标题
重症肌无力合并膜性肾病，通过扩大胸腺全切除术成功治疗。
DOI：
10.2169/internalmedicine.39.490
复制
发表时间：
2000
影响因子：
1.2
通讯作者：
H. Ishigame
中科院分区：
文献类型：
--
作者：
M. Matsuda;J. Miki;K. Tabata;M. Ikezoe;N. Nishizawa;H. Ishigame
一位46岁女性在左眼睑下垂后出现蛋白尿和血尿，并在肾活检时发现膜性肾病（MN）的组织病理学。她被诊断为患有重症肌无力（MG），因为阳性的埃络试验和血清中的抗乙酰胆碱受体（AchR）抗体。我们发现，在扩大全胸腺切除术后，抗AchR抗体减少，同时泌尿系统检查结果和肌无力症状改善。本例MG先于MN，胸腺切除术对两种疾病均有效，提示胸腺可能在MN的发病中起重要作用。
A 46-year-old woman showed proteinuria and hematuria after left blepharoptosis, and revealed a histopathology of membranous nephropathy (MN) at renal biopsy. She was diagnosed as having myasthenia gravis (MG) because of a positive edrophonium test and anti-acetylcholine receptor (AchR) antibodies in serum. We found a decrease in anti-AchR antibodies after extended total thymectomy, in parallel with an improvement in both urinary findings and myasthenic symptoms. In this case, MG preceded MN and the thymectomy was effective for both diseases, suggesting that the thymus might play an important role in the pathogenesis of MN.