AMINERGIC MODULATION IN LOBSTER STOMATOGASTRIC GANGLION .1. EFFECTS ON MOTOR PATTERN AND ACTIVITY OF NEURONS WITHIN THE PYLORIC CIRCUIT
AMINERGIC MODULATION IN LOBSTER STOMATOGASTRIC GANGLION .1. EFFECTS ON MOTOR PATTERN AND ACTIVITY OF NEURONS WITHIN THE PYLORIC CIRCUIT
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DOI：
10.1152/jn.1986.55.5.847
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发表时间：
1986-05-01
影响因子：
2.5
通讯作者：
HARRISWARRICK, RM
中科院分区：
文献类型：
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作者：
FLAMM, RE;HARRISWARRICK, RM
我们研究了多巴胺、章鱼胺和5-羟色胺对龙虾口胃神经节幽门回路运动输出的影响。在10（-8）至10（-4）M的浓度下，对胺进行浴涂，并在细胞内和细胞外监测六类幽门神经元的反应。每种胺都以特定的方式改变幽门运动模式。此外，多巴胺和章鱼胺在不同浓度下都能产生不同的运动模式。胺对幽门神经元的影响包括启动和增强或抑制锋电位活动，神经元相位关系的变化，以及幽门节律周期频率的变化。这些结果表明，这个研究中心模式发生器电路产生的运动模式是高度可塑性的，可以通过内源性生物胺调制。
We investigated the effects of dopamine, octopamine, and serotonin on the motor output of the pyloric circuit in the stomatogastric ganglion of the lobster, Panulirus interruptus. Amines were bath applied at concentrations from 10(-8) to 10(-4) M, and the responses of the six classes of pyloric neurons were monitored both intracellularly and extracellularly. Each amine modified the pyloric motor pattern in a specific way. In addition, dopamine and octopamine were each able to produce different motor patterns at different concentrations. Amine effects on pyloric neurons included initiation and enhancement or inhibition of spike activity, changes in the phase relationships of neurons, and changes in the cycle frequency of the pyloric rhythm. These results show that the motor pattern produced by this well-studied central pattern generator circuit is highly plastic and can be modulated by endogenous biogenic amines.