Presynaptic cyclic nucleotide-gated ion channels modulate neurotransmission in the mammalian olfactory bulb.
Presynaptic cyclic nucleotide-gated ion channels modulate neurotransmission in the mammalian olfactory bulb.
复制标题
突触前环核苷酸门控离子通道调节哺乳动物嗅球的神经传递。
DOI：
10.1016/s0896-6273(03)00057-6
复制
发表时间：
2003
期刊：
影响因子：
16.2
通讯作者：
Isaacson,JeffryS
中科院分区：
文献类型：
--
作者：
Murphy,GabeJ;Isaacson,JeffryS
嗅觉受体神经元树突纤毛上的环核苷酸门控通道（CNGCs）在嗅觉系统的感觉传导中起着至关重要的作用。CNGCs是否也在orn的轴突和/或神经末梢发挥作用？我们发现环核苷酸cAMP和cGMP可以促进和抑制嗅神经纤维与嗅球肾小球内靶点之间的突触传递。环核苷酸增加ORN末端细胞内Ca2+，促进自发递质释放；在较高浓度下，环核苷酸通过改变嗅觉神经兴奋性来抑制诱发传递。然而，在缺乏嗅觉CNGCs的小鼠中，环核苷酸对传递或神经兴奋性没有影响。综上所述，我们的研究结果确定了突触前CNGCs在调节神经传递中的新作用。
Cyclic nucleotide-gated channels (CNGCs) on the dendritic cilia of olfactory receptor neurons (ORNs) are critical for sensory transduction in the olfactory system. Do CNGCs also play a role in the axons and/or nerve terminals of ORNs? We find that the cyclic nucleotides cAMP and cGMP can both facilitate and depress synaptic transmission between olfactory nerve fibers and their targets in olfactory bulb glomeruli. Cyclic nucleotides increase intracellular Ca2+in ORN terminals and enhance spontaneous transmitter release; at higher concentrations, cyclic nucleotides depress evoked transmission by altering olfactory nerve excitability. Cyclic nucleotides have no effect on transmission or nerve excitability, however, in mice lacking olfactory CNGCs. Taken together, our results identify a novel role for presynaptic CNGCs in modulating neurotransmission.