Cross-modal synaptic plasticity in adult primary sensory cortices.
Cross-modal synaptic plasticity in adult primary sensory cortices.
复制标题
成人初级感觉皮层中的跨模式突触可塑性。
DOI：
10.1016/j.conb.2015.08.002
复制
发表时间：
2015-12
影响因子：
5.7
通讯作者：
Whitt JL
中科院分区：
文献类型：
--
作者：
Lee HK;Whitt JL
感觉丧失导致大脑回路的广泛适应，以允许生物体用其剩余的感觉导航其环境，这被广泛地称为跨模态可塑性。这种适应甚至可以在初级感觉皮层中观察到，并分为两种不同的类别：(1)被剥夺的感觉皮层用于处理剩余的感觉，我们称之为“跨模态补充”；(2)被称为“代偿可塑性”的剩余感觉皮层的经验依赖细化。在这里，我们将回顾最近的研究，这些研究表明皮层对感觉丧失的适应涉及LTP/LTD和稳态突触可塑性。在成人中观察到突触的跨模态可塑性，因此跨模态感觉剥夺可能是促进成人初级感觉皮质可塑性的有效途径。
Sensory loss leads to widespread adaptation of brain circuits to allow an organism to navigate its environment with its remaining senses, which is broadly referred to as cross-modal plasticity. Such adaptation can be observed even in the primary sensory cortices, and falls into two distinct categories: (1) recruitment of the deprived sensory cortex for processing the remaining senses, which we term “cross-modal recruitment”, and (2) experience-dependent refinement of the spared sensory cortices referred to as “compensatory plasticity.” Here we will review recent studies demonstrating that cortical adaptation to sensory loss involves LTP/LTD and homeostatic synaptic plasticity. Cross-modal synaptic plasticity is observed in adults, hence cross-modal sensory deprivation may be an effective way to promote plasticity in adult primary sensory cortices.