In vivo validation of the design rules of the coronary arteries and their application in the assessment of diffuse disease
In vivo validation of the design rules of the coronary arteries and their application in the assessment of diffuse disease
复制标题
冠状动脉设计规则的体内验证及其在弥漫性疾病评估中的应用
DOI：
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Sabee Molloi
中科院分区：
文献类型：
--
作者：
Yifang Zhou;Ghassan S Kassab;Sabee Molloi
The conventional rationale that uses per cent diameter reduction to assess diffuse coronary artery disease is not appropriate because no normal reference segments exist. In a recent publication, we have proposed a theoretical model based on physical principles that relate the various morphological and haemodynamic parameters (cross-sectional area, length, volume and flow) of the normal coronary arterial tree. The model was validated using haemodynamic simulations based on detailed morphological data of the pig coronary arterial tree. This paper extends the model validation to in vivo swine studies. Coronary arteriography was performed in five swine (15–18 kg body weight) after power injection of contrast material into the coronary artery. Coronary arterial length was obtained using a 3D reconstruction technique. The arterial volume, cross-sectional area and blood flow were measured using videodensitometry. The proposed relationships between these quantities were validated. Furthermore, a sensitivity analysis was demonstrated based on a simulation of diffuse coronary artery disease (approximately 40% reduction in cross-sectional area). The results of a sensitivity analysis based on a simulation of diffuse coronary artery disease suggest that the relationships between arterial volume, cross-sectional area, blood flow and the distal arterial length can be utilized to quantify moderate levels of diffuse coronary artery disease.
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X 射线束均衡：模型和猪中自动化原型系统的可行性和性能。
DOI：
10.1148/radiol.2213010183
发表时间：
2001
期刊：
Radiology.
影响因子：
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作者：
Molloi,S;VanDrie,A;Wang,F
通讯作者：
Wang,F
在三起经皮冠状动脉腔内成形术致命病例中，血管造影未能准确描述冠状动脉狭窄的程度。
影响因子：
24
作者：
Dietz,WA;Tobis,JM;Isner,JM
通讯作者：
Isner,JM
评估患者冠状动脉阻塞的生理意义：弥漫性未检测到的动脉粥样硬化的重要性。
影响因子：
9.1
作者：
Marcus,ML;Harrison,DG;White,CW;McPherson,DD;Wilson,RF;Kerber,RE
通讯作者：
Kerber,RE
影响因子：
--
作者：
KASSAB, GS;RIDER, CA;FUNG, YCB
通讯作者：
FUNG, YCB