Anorganic bovine matrix/P-15 "flow" in the treatment of periodontal defects: Case series with 12 months of follow-up
Anorganic bovine matrix/P-15 "flow" in the treatment of periodontal defects: Case series with 12 months of follow-up
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DOI：
10.1902/jop.2006.050161
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发表时间：
2006-07-01
影响因子：
4.3
通讯作者：
Palioto, Daniela B.
中科院分区：
文献类型：
--
作者：
Barros, Raquel R. M.;Novaes, Arthur B., Jr.;Palioto, Daniela B.
背景：如今，开发可以促进特定部位伤口愈合的生物疗法成为一种趋势。在这方面，将由合成肽（P-15）提供的I型胶原蛋白的细胞结合活性掺入支架（无机牛基质[ABM]）中以促进细胞的附着、迁移和分化。这个病例系列介绍了一个外科协议的位置ABM/P-15“流”在regenerative procedures.Methods：宽牙周缺损进行了治疗与沟切口保留乳头，全厚皮瓣反射，肉芽组织清创，机械和化学根表面处理，放置的ABM/P-15“流”，伤口缝合。每周，然后每月，deplaquing进行，直到12个月的术后回忆，其中的临床参数进行了reevaluated.Results：显着的临床变化，包括探测深度减少和相对临床附着水平增益，12个月后实现。的X光片表现出增加不透射线性相比，最初采取的，这表明硬组织improvements.Conclusions：这里描述的缺陷的地形可以理解为一个挑战，再生，一旦以前的故障的支持组织减少了愈合过程中的细胞来源，并减少了数量的残余壁保留移植材料。因此，看来ABM/P-15“流动”有助于取得临床成功。基于此结果，ABM/P-15“流动”可能是一种有用的和有益的材料，用于治疗牙周缺损。
Background: Nowadays there is a trend in developing biologic modalities that may enhance wound healing of specific sites. In this regard, a cell-binding activity of type I collagen provided by a synthetic peptide (P-15) was incorporated in a scaffold (anorganic bovine matrix [ABM]) to facilitate the attachment, migration, and differentiation of cells. This case series describes a surgical protocol for the placement of ABM/P-15 "flow" during regenerative procedures.Methods: Wide periodontal defects were treated with sulcular incisions preserving the papillae, full-thickness flap reflection, granulation tissue debridement, mechanical and chemical root surface treatment, placement of the ABM/P-15 "flow," and wound-closure sutures. Weekly, and then monthly, deplaquing was performed until the 12-month postoperative recall, in which the clinical parameters were reevaluated.Results: Significant clinical changes, including probing depth reduction and relative clinical attachment level gain, were achieved after the 12-month period. The radiographs demonstrated increase in radiopacity when compared to those taken initially, suggesting hard tissue improvements.Conclusions: The topography of the defects described here could be understood as a challenge for regeneration, once the previous breakdown of the supporting tissues had diminished the source of cells for the healing process and reduced the number of residual walls to retain the graft material. Thus, it seems that the ABM/P-15 "flow" contributed to the clinical success achieved. Based on this result, ABM/P-15 "flow" could be a useful and beneficial material for the treatment of periodontal defects.