The protective effect of antibody in immunity to murine chlamydial genital tract reinfection is independent of immunoglobulin A.
The protective effect of antibody in immunity to murine chlamydial genital tract reinfection is independent of immunoglobulin A.
复制标题
抗体对小鼠衣原体生殖道再感染的免疫保护作用与免疫球蛋白 A 无关。
DOI：
10.1128/iai.73.9.6183-6186.2005
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发表时间：
2005
影响因子：
3.1
通讯作者：
Morrison,RichardP
中科院分区：
文献类型：
--
作者：
Morrison,SandraG;Morrison,RichardP
The resolution of primary and secondary chlamydial genital infection in immunoglobulin A (IgA)-deficient (IgA−/−) mice was not different from that in IgA+/+mice. Furthermore, depletion of either CD4+or CD8+T cells prior to reinfection of IgA+/+or−/−mice had limited impact on immunity to reinfection. Thus, although antibody contributes importantly to immunity to chlamydial genital tract reinfection, IgA antibodies are not an absolute requirement of that protective response.
