不对称Kabachnik-Fields 反应合成研究进展
不对称Kabachnik-Fields 反应合成研究进展
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DOI：
10.6023/cjoc114224
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发表时间：
2012
影响因子：
1.9
通讯作者：
万德慧;吴明书;马静雅
中科院分区：
文献类型：
--
作者：
万德慧;吴明书;马静雅
Asymmetric three-component Kabachnik-Field reaction for the stereoselective synthesis of optically active α-amino phosphonates has been received considerable attention due to their great intrinsic advantages as well as their applica- tions in drug discovery. This review covers recent progress on asymmetric three-component Kabachnik-Field reaction includ- ing the chiral catalysts and optical active substrate induction approaches to chiral α-aminoalkylphosphonic acid derivatives. The influence of the chiral catalysts and reaction substrate configuration on the reaction stereoselectivity is the major focus. It elicits issues and perspectives of asymmetric three-component Kabachnik-Field reaction in the end. Keywords Kabachnik-Fields reaction; asymmetric synthesis; chiral α-aminoalkylphosphonic acid 多组分反应(multicomponent reactions, MCRs)是指