Asymmetric synthesis of 3,4-dihydrocoumarins by rhodium-catalyzed reaction of 3-(2-hydroxyphenyl)cyclobutanones
Asymmetric synthesis of 3,4-dihydrocoumarins by rhodium-catalyzed reaction of 3-(2-hydroxyphenyl)cyclobutanones
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DOI：
10.1021/ja075141g
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发表时间：
2007-10-10
影响因子：
15
通讯作者：
Murakami, Masahiro
中科院分区：
文献类型：
--
作者：
Matsuda, Takanori;Shigeno, Masanori;Murakami, Masahiro
以3-(2-羟基苯基)环丁酮为原料，通过对映选择性碳-碳键断裂，以高度对映选择性的方式合成了3,4-二氢香豆素衍生物。与缺电子烯烃的级联反应在二氢香豆素的 5 位引入了碳-碳键。
3,4-Dihydrocoumarin derivatives were synthesized in a highly enantioselective manner from 3-(2-hydroxyphenyl)cyclobutanones through enantioselective carbon-carbon bond cleavage. A cascade reaction with electron-deficient alkenes introduced a carbon-carbon bond at the 5-position of the dihydrocoumarins.