Uterine natural killer cells in patients with idiopathic recurrent miscarriage
Uterine natural killer cells in patients with idiopathic recurrent miscarriage
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DOI：
10.1111/aji.12721
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发表时间：
2017-10-01
影响因子：
3.6
通讯作者：
Toth, Bettina
中科院分区：
文献类型：
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作者：
Kuon, Ruben-J.;Weber, Maja;Toth, Bettina
问题：子宫自然杀手（uNK）细胞是着床和妊娠早期的主要参与者。本研究的目的是分析特发性复发性流产（iRM）患者和生育对照组子宫内膜中的uNK细胞浓度。研究方法：在n=130对连续>= 3的夫妇中，根据标准化诊断方案筛选临床RM，确定n=58例iRM患者。采用免疫组化方法对患者和17例育龄妇女（对照组）进行子宫内膜活检。结果：与对照组相比，iRM患者的uNK细胞浓度显著升高（257 +/- 212 vs 148 +/- 73 /mm） (2)， P= 0.04)。IRM患者的uNK细胞/mm(2)的发生率高于对照组（34.5% vs. 5.9%， P= 0.02）。在88%的对照组和62%的iRM患者中，检测到的uNK细胞在40-300/mm范围内(2)。结论：特发性复发性流产患者的uNK细胞水平高于对照组，支持uNK细胞在流产病理生理中的可能影响。我们的截止水平可能有助于选择可能受益于免疫调节治疗的RM患者。
Problem: Uterine natural killer (uNK) cells are major players during implantation and early pregnancy. The aim of our study was to analyze uNK cell concentration in the endometrium of idiopathic recurrent miscarriage (iRM) patients and fertile controls.Method of study: Out of n=130 couples with >= 3 consecutive, clinical RM screened according to a standardized diagnostic protocol, n=58 patients with iRM were identified. Endometrial biopsies were investigated in patients and n=17 fertile women (controls) via immunohistochemistry.Results: Compared to controls, the concentration of uNK cells was significantly higher in iRM patients (257 +/- 212 vs. 148 +/- 73 uNK cells/mm(2), P=.04). IRM patients showed a higher prevalence of >300 uNK cells/mm(2) than controls (34.5% vs. 5.9%, P=.02). In 88% of controls and 62% of iRM patients, uNK cells were detected within the range of 40-300/mm(2).Conclusion: Idiopathic recurrent miscarriage patients showed higher uNK cell levels than controls supporting the possible impact of uNK cells in the pathophysiology of miscarriage. Our cutoff levels might help to select RM patients which may benefit from immunomodulatory treatment.