A NEW METHOD FOR THE GENERATION AND USE OF FOCUSED ULTRASOUND IN EXPERIMENTAL BIOLOGY.
A NEW METHOD FOR THE GENERATION AND USE OF FOCUSED ULTRASOUND IN EXPERIMENTAL BIOLOGY.
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DOI：
10.1085/jgp.26.2.179
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发表时间：
1942-11-20
期刊：
影响因子：
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通讯作者：
Miller AE
中科院分区：
文献类型：
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作者：
Lynn JG;Zwemer RL;Chick AJ;Miller AE
1. 设计、建造并成功运行了高效聚焦超声发生器。 2. 发生器已用于在石蜡块的中心产生局部加热，并且以类似的方式，在新鲜肝组织深处获得破坏的局部区域，对表面的影响最小，并且对中间组织没有影响。 3. 在动物中，高强度聚焦超声产生了局部大脑变化，这可以从行为障碍中推断出来，并在尸检中得到证实。这种局部脑效应是通过干预头皮、头骨和脑膜来实现的。由此产生的行为障碍在 2 至 16 小时内消失。 4. 迄今为止，尚不可能在不对辐射锥底部的皮肤和皮下组织造成意外伤害的情况下产生这种大脑变化。 5.建议对聚焦超声束的产生和应用进行改进，由此应该有可能进一步增加大脑中的焦点效应，从而相应地减少或消除复杂的表面损伤。
1. An efficient generator of focused ultrasound has been designed, built, and successfully operated. 2. The generator has been used to produce focal heating in the centers of paraffin blocks, and in a similar manner, focal areas of destruction were obtained deep in fresh liver tissue with minimal effects at the surface and no effects on the intervening tissue. 3. In animals, focused ultrasound of high intensity produced local cerebral changes as inferred from behavior disabilities and as demonstrated at autopsy. This local brain effect was achieved through intervening scalp, skull, and meninges. The resulting behavior disabilities disappeared in from 2 to 16 hours. 4. To date, it has not been possible to produce such brain changes without incidental injury to the skin and subcutaneous tissue lying at the base of the cone of radiation. 5. Improvements in generation and application of the focused supersonic beam are suggested whereby it should be possible to increase still further the focal effects in the brain, with a corresponding decrease or elimination of complicating surface injury.