MOR23 promotes muscle regeneration and regulates cell adhesion and migration.
MOR23 promotes muscle regeneration and regulates cell adhesion and migration.
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DOI：
10.1016/j.devcel.2009.09.004
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发表时间：
2009-11
影响因子：
11.8
通讯作者：
Pavlath GK
中科院分区：
文献类型：
--
作者：
Griffin CA;Kafadar KA;Pavlath GK
嗅觉上皮中的气味受体（OR）结合挥发性小分子，导致嗅觉的感知。OR在许多组织中表达，但其功能在很大程度上是未知的。我们发现多个OR在体外肌形成和体内肌肉再生过程中显示出不同的mRNA表达模式。小鼠OR23（MOR23）表达在肌肉再生期间当肌肉细胞广泛融合时被诱导，并且在体外调节肌肉细胞的迁移和粘附中起关键作用，这是组织修复期间常见的两个过程。M0R 23的可溶性配体在体外由肌肉细胞分泌，在体内由肌肉组织分泌。M0R 23对于适当的骨骼肌再生是必需的，因为M0R 23的损失导致肌纤维分支增加，通常与肌营养不良症相关。这些数据共同确定了鼻外手术室的功能作用，并表明手术室在组织修复过程中的作用更大。
Odorant receptors (ORs) in the olfactory epithelium bind to volatile small molecules leading to the perception of smell. ORs are expressed in many tissues but their functions are largely unknown. We show multiple ORs display distinct mRNA expression patterns during myogenesis in vitro and muscle regeneration in vivo. Mouse OR23 (MOR23) expression is induced during muscle regeneration when muscle cells are extensively fusing and plays a key role in regulating migration and adhesion of muscle cells in vitro, two processes common during tissue repair. A soluble ligand for MOR23 is secreted by muscle cells in vitro and muscle tissue in vivo. MOR23 is necessary for proper skeletal muscle regeneration as loss of MOR23 leads to increased myofiber branching, commonly associated with muscular dystrophy. Together these data identify a functional role for an OR outside of the nose and suggest a larger role for ORs during tissue repair.
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影响因子：
64.5
作者：
Serizawa, Shou;Miyamichi, Kazunari;Sakano, Hitoshi
通讯作者：
Sakano, Hitoshi
影响因子：
2.7
作者：
Kafadar, Kimberly A.;Yi, Lin;Ahmad, Yusra;So, Leslie;Rossi, Fabio;Pavlath, Grace K.
通讯作者：
Pavlath, Grace K.
影响因子：
5.5
作者：
Bondesen, BA;Mills, ST;Pavlath, GK
通讯作者：
Pavlath, GK
影响因子：
7.8
作者：
Beggs, ML;Nagarajan, R;Peterson, CA
通讯作者：
Peterson, CA
DOI：
10.1016/s0006-291x(03)00863-5
发表时间：
2003-06-13
影响因子：
3.1
作者：
Katada, S;Nakagawa, T;Touhara, K
通讯作者：
Touhara, K