Conditioned changes in nucleus accumbens dopamine signal established by intravenous cocaine in rats
Conditioned changes in nucleus accumbens dopamine signal established by intravenous cocaine in rats
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DOI：
10.1016/0304-3940(96)12731-2
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发表时间：
1996-06-21
影响因子：
2.5
通讯作者：
Stein, EA
中科院分区：
文献类型：
--
作者：
Kiyatkin, EA;Stein, EA
为了探讨可卡因诱导的条件反射在调节中脑边缘多巴胺（DA）活性中的作用，使用Nafion涂层碳纤维电极的高速计时电流法测量先前与静脉注射可卡因（0.85 mg/kg/注射）配对和不配对的光刺激诱导的中脑边缘核（NAc）DA依赖性信号的变化，以及与光配对和不配对的可卡因注射。未用药大鼠在光照后发现小的阶段性DA信号增加，而相同的光与可卡因重复配对后诱导了更大、更长时间的信号增加。DA信号的变化与重复可卡因注射与光配对不同于单独可卡因诱导和药物自我管理过程中发生的。这些数据表明，可卡因相关的感觉线索，单独作用，可能会引起条件性中脑边缘DA激活，并在药物的存在下，可能会显着修改DA反应的药物。
To explore the role of cocaine-induced conditioning in the regulation of mesolimbic dopamine (DA) activity, high-speed chronoamperometry with Nafion-coated carbon fiber electrodes was used to measure changes in nucleus accumbens (NAc) DA-dependent signal induced by a light stimulus previously paired and not paired with intravenous cocaine (0.85 mg/kg per injection), and cocaine injections paired and not paired with light. A small phasic DA signal increase was found after light presentation in drug-naive rats, whereas greater and longer signal increases were induced by the same light after it had been repeatedly paired with cocaine. The DA signal changes associated with repeated cocaine injections paired with light differed from those induced by cocaine alone and occurring during drug self-administrations. These data suggest that cocaine-related sensory cues, acting alone, may induce a conditioned mesolimbic DA activation, and, acting in the presence of the drug, may significantly modify the DA response to the drug.