Chronic decrease in wakefulness and disruption of sleep-wake behavior after experimental traumatic brain injury.
Chronic decrease in wakefulness and disruption of sleep-wake behavior after experimental traumatic brain injury.
复制标题
实验性脑外伤后觉醒度慢性下降和睡眠-觉醒行为破坏。
DOI：
10.1089/neu.2014.3664
复制
发表时间：
2015
影响因子：
4.2
通讯作者：
Faden,AlanI
中科院分区：
文献类型：
--
作者：
Skopin,MarkD;Kabadi,ShrutiV;Viechweg,ShaunS;Mong,JessicaA;Faden,AlanI
Traumatic brain injury (TBI) can cause sleep-wake disturbances and excessive daytime sleepiness. The pathobiology of sleep disorders in TBI, however, is not well understood, and animal models have been underused in studying such changes and potential underlying mechanisms. We used the rat lateral fluid percussion (LFP) model to analyze sleep-wake patterns as a function of time after injury. Rapid-eye movement (REM) sleep, non-REM (NREM) sleep, and wake bouts during light and dark phases were measured with electroencephalography and electromyography at an early as well as chronic time points after LFP. Moderate TBI caused disturbances in the ability to maintain consolidated wake bouts during the active phase and chronic loss of wakefulness. Further, TBI resulted in cognitive impairments and depressive-like symptoms, and reduced the number of orexin-A-positive neurons in the lateral hypothalamus.
