Magnesium requirements: new estimations for men and women by cross-sectional statistical analyses of metabolic magnesium balance data
Magnesium requirements: new estimations for men and women by cross-sectional statistical analyses of metabolic magnesium balance data
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DOI：
10.1093/ajcn/84.4.843
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发表时间：
2006-10-01
影响因子：
7.1
通讯作者：
Johnson, LuAnn K.
中科院分区：
文献类型：
--
作者：
Hunt, Curtiss D.;Johnson, LuAnn K.
背景资料：目前对镁需要量的建议是基于稀疏平衡数据。目的：为了提供男性和女性平均镁需要量的新估计，我们汇总了来自美国农业部农业研究服务中心大福克斯人类营养研究中心（大福克斯，ND）进行的27项严格控制平衡研究的镁数据。设计：镁平衡数据（镁摄入量- [粪便镁+尿镁]）从243名受试者中收集了664个数据点（女性：n = 150;体重：71.6 ± 16.5 kg;年龄：51.3 ± 17.4岁;男性：n = 93，体重：76.3 ± 12.5 kg;年龄：28.1 ± 8.1岁）。分析了每项研究中每个饮食期（>= 28 d）最后6-14 d的数据，如果个体摄入钙，则排除。铜、铁、磷或锌低于1994年个人食物摄入量持续调查中这些元素的估计平均需要量（EARS）或超过这些元素通常摄入量的99分之一（铁：高于上限）。镁的每日摄入量在84至598毫克之间。结果：在镁摄入量为165 mg/d [95%预测区间（PI）：113，237 mg/d; Y = 19.8 + 0.880 M]，2.36 mg/d [95%预测区间（PI）：113，237 mg/d; kg（-1）（.）d（-1）（95%PI-1.581，3.38 mg（.）kg（-1）（.）d（-1）; Y = 0.306 + 0.870 M）或0.075 mg（.）千卡（-1）d（-1）（95%PI：0.05，0.11 mg（.）千卡（-1）d（-1）; Y = 0.011 + 0.857 M）。年龄和性别都不影响镁摄入量和输出之间的关系。结论：研究结果表明，健康男性和女性的镁需求量低于以前估计。
Background: Current recommendations for magnesium requirements are based on sparse balance data.Objective: To provide new estimates of the average magnesium requirement for men and women, we pooled magnesium data from 27 different tightly controlled balance studies conducted at the US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND.Design: Magnesium balance data (magnesium intake - [fecal magnesium + urinary magnesium]) (664 data points) were collected from 243 subjects (women: n = 150; weight: 71.6 +/- 16.5 kg; age: 51.3 +/- 17.4 y; men: n = 93, weight: 76.3 +/- 12.5 kg; age: 28.1 +/- 8.1 y). Data from the last 6-14 d of each dietary period (>= 28 d) of each study were analyzed and were excluded if individual intakes of calcium. copper, iron, phosphorus, or zinc fell below respective estimated average requirements (EARs) or exceeded 99th percentiles of usual intakes of those elements (iron: above the upper limit) from the 1994 Continuing Survey of Food Intakes by Individuals. Daily intakes of magnesium ranged between 84 and 598 mg. The relation between magnesium intake and magnesium output was investigated by fitting random coefficient models.Results: The models predicted neutral magnesium balance [defined as magnesium output (Y) equal to magnesium intake (M)] at magnesium intakes of 165 mg/d [95% prediction interval (Pl): 113, 237 mg/d; Y = 19.8 + 0.880 M], 2.36 mg (.) kg(-1) (.) d(-1) (95% PI-1.581, 3.38 mg (.) kg(-1) (.) d(-1); Y = 0.306 + 0.870 M), or 0.075 mg (.) kcal(-1) (.) d(-1) (95% PI: 0.05, 0.11 mg (.) kcal(-1) (.) d(-1); Y = 0.011 + 0.857 M). Neither age nor sex affected the relation between magnesium intake and output.Conclusion: The findings suggest a lower magnesium requirement for healthy men and women than estimated previously.