Dream-enacting behaviour is associated with impaired sleep and severe headache-related disability in migraine patients
Dream-enacting behaviour is associated with impaired sleep and severe headache-related disability in migraine patients
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DOI：
10.1177/0333102413477742
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发表时间：
2013-07-01
期刊：
影响因子：
4.9
通讯作者：
Hirata, Koichi
中科院分区：
文献类型：
--
作者：
Suzuki, Keisuke;Miyamoto, Tomoyuki;Hirata, Koichi
背景偏头痛患者存在睡眠障碍、噩梦和视觉幻觉，提示偏头痛与快速眼动(REM)睡眠调节有关。然而，偏头痛与快速眼动睡眠行为障碍(RBD)之间的关系尚不清楚。方法通过一项横断面病例对照研究，我们评估了偏头痛发作期患者(n=161，平均年龄33.1岁)和非头痛对照组(n=140，平均年龄33.1岁)偏头痛患者做梦行为(DEB)的临床相关性。结果偏头痛患者的DEB发生率显著高于对照组(24.2%比14.3%)。与没有DEB的患者相比，患有DEB的偏头痛患者在偏头痛残疾评估和匹兹堡睡眠质量指数上的得分更高，吸烟率也更高。有无DEB的偏头痛患者的病程、头痛频率和强度无明显差异。结论DEB与偏头痛患者的睡眠障碍和严重的头痛相关功能障碍有关，可能反映了偏头痛患者的脑干功能障碍和脑兴奋性增加。
BackgroundSleep disorders, nightmares and visual hallucinations have been reported in migraine patients, which may suggest the involvement of rapid eye movement (REM) sleep regulation in migraine. However, the relationship between migraine and REM sleep behaviour disorder (RBD) remains unclear.MethodsTo investigate the clinical correlates of dream-enacting behaviours (DEB) in migraine patients, we assessed episodic migraine patients (n=161, mean age 33.1 years) and headache-free control subjects (n=140, mean age 33.1 years) under 50 years of age in a cross-sectional, case-control study. The Japanese version of the RBD screening questionnaire was used, and subjects scoring 5 or higher were defined as having DEB.ResultsA significantly increased frequency of DEB was observed in migraine patients compared to controls (24.2% vs. 14.3%). Migraine patients with DEB presented higher scores on the Migraine Disability Assessment and Pittsburgh Sleep Quality Index and an increased rate of smoking compared to those without DEB. Duration of migraine and headache frequency and intensity were not different between migraine patients with or without DEB.ConclusionDEB was associated with impaired sleep and severe headache-related disability in migraine patients and may reflect brainstem dysfunction and increased brain excitability in migraine patients.