Rapid microfluidic mixing via rotating magnetic microbeads
Rapid microfluidic mixing via rotating magnetic microbeads
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DOI：
10.1016/j.sna.2016.09.040
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发表时间：
2016-11-01
影响因子：
4.6
通讯作者：
Hesketh, Peter J.
中科院分区：
文献类型：
--
作者：
Owen, Drew;Ballard, Matthew;Hesketh, Peter J.
本文提出了一种通过旋转磁性微珠阵列在微流体通道中进行混合的新方法。微珠围绕圆形坡莫合金（NiFe）特征旋转，所述圆形坡莫合金（NiFe）特征被旋转外部磁场磁化。该系统在短通道长度内表现出快速混合。该系统的有效性通过分析两个流的混合程度来量化，一个流具有荧光，一个流不具有荧光。我们的实验和数值模拟表明，与沿通道向下流动相比，以高速度绕轨道运行的珠粒导致流体形成圆形冠状物，该圆形冠状物横跨微通道延伸，从而导致流体混合。在这些条件下，旋转的磁性微珠能够在270 μ m的混合区域中充分混合流。(C)2016由Elsevier B.V.出版
Presented here is a novel method for mixing in a microfluidic channel via an array of rotating magnetic microbeads. The microbeads rotate around circular permalloy (NiFe) features magnetized by a rotating external magnetic field. This system demonstrates rapid mixing in short channel lengths. The effectiveness of this system is quantified by analyzing the degree of mixing of two streams, one with fluorescence and one without. Our, experiments and numerical simulations reveal that beads orbiting at a high velocity as compared to flow down the channel cause the fluid to form circular coronae that stretch across the microchannel leading to fluid mixing. Under these conditions, rotating magnetic microbeads were able to fully mix the streams in a 270 mu m mixing region. (C) 2016 Published by Elsevier B.V.