Application of sensitivity-encoded echo-planar imaging for blood oxygen level-dependent functional brain imaging
Application of sensitivity-encoded echo-planar imaging for blood oxygen level-dependent functional brain imaging
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DOI：
10.1002/mrm.10303
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发表时间：
2002-12-01
影响因子：
3.3
通讯作者：
Duyn, JH
中科院分区：
文献类型：
--
作者：
de Zwart, JA;van Gelderen, P;Duyn, JH
在1.5T下，定量研究了基于血氧水平依赖(BOLD)对比度的功能磁共振(FMRI)的灵敏度编码(SENSE)回波平面成像(EPI)的益处。在分辨率为3.4 x 3.4 x 4.0 mm(3)的实验中，SENSE使单次EPI图像采集时间从24.1 ms缩短到12.4 ms，从而降低了对几何失真和T-2*模糊的敏感度。对8名正常志愿者进行的手指敲击功能磁共振实验显示，激活区域的t分数总体下降了18%，根据图像信噪比(SNR)和g因子，这一下降幅度明显小于预期，但与考虑生理噪声的模型预测的损失相似。
The benefits of sensitivity-encoded (SENSE) echo-planar imaging (EPI) for functional MRI (fMRI) based on blood oxygen level-dependent (BOLD) contrast were quantitatively investigated at 1.5 T. For experiments with 3.4 x 3.4 x 4.0 mm(3) resolution, SENSE allowed the single-shot EPI image acquisition duration to be shortened from 24.1 to 12.4 ms, resulting in a reduced sensitivity to geometric distortions and T-2* blurring. Finger-tapping fMRI experiments, performed on eight normal volunteers, showed an overall 18% loss in t-score in the activated area, which was substantially smaller than expected based on the image signal-to-noise ratio (SNR) and g-factor, but similar to the loss predicted by a model that takes physiologic noise into account.