Moesin facilitates metastasis of hepatocellular carcinoma cells by improving invadopodia formation and activating β-catenin/MMP9 axis
Moesin facilitates metastasis of hepatocellular carcinoma cells by improving invadopodia formation and activating β-catenin/MMP9 axis
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DOI：
10.1016/j.bbrc.2020.01.157
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发表时间：
2020-04-16
影响因子：
3.1
通讯作者：
Wang, Yingchao
中科院分区：
文献类型：
--
作者：
Lan, Shubing;Zheng, Xiaoyuan;Wang, Yingchao
Moesin已被证明与许多其他癌症的侵袭和转移有关，但在肝细胞癌中尚不清楚。因此，本研究旨在探讨moesin在肝细胞癌中的临床意义及其生物学功能。结果表明，Moesin在肝癌组织中显著上调，是预测肝癌患者术后复发的独立预后因素。此外，我们还证明了Moesin在体外和体内都促进了肝癌细胞的迁移和侵袭。机制研究表明，过表达moesin增加了不动足的形成，并促进了β-catenin/MMP9轴的激活。综上所述，我们的研究结果表明，Moesin在参与肝癌转移的过程中发挥了重要的癌蛋白作用。(C)2020 Elsevier Inc.保留所有权利。
Moesin has been proved to be implicated in invasiveness and metastasis in many other cancers, but unclear in HCC. Thus, this study was performed to investigate the clinical significance of moesin and its biological functions in HCC. The results showed that moesin was significantly up-regulated in HCC tissues and was an independent prognostic factor for predicting the recurrence of HCC patients, postoperatively. Furthermore, we also demonstrated that moesin promoted the migration and invasion of HCC cells in vitro and in vivo. And the mechanism studies indicated that moesin overexpression increased the formation of invadopodia and improved the activation of beta-catenin/MMP9 axis. Taken together, our findings revealed that moesin acted as an important onco-protein participating in the metastasis of HCC. (C) 2020 Elsevier Inc. All rights reserved.