Apoptotic and proliferative markers in chordomas: a study of 26 tumors.
Apoptotic and proliferative markers in chordomas: a study of 26 tumors.
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脊索瘤中的凋亡和增殖标志物：对 26 种肿瘤的研究。
DOI：
10.1053/adpa.2002.35397
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发表时间：
2002
影响因子：
2
通讯作者：
R. Prayson
中科院分区：
文献类型：
--
作者：
Sony P Kilgore;R. Prayson
很少有研究探讨细胞增殖和凋亡标志物在脊索瘤中的作用。本研究回顾性分析了26例脊索瘤的临床病理特征，并检测了MIB-1、p53、bcl-2和细胞周期蛋白D1在这些肿瘤中的免疫反应性。患者年龄范围为34 - 78岁（平均60.7岁），包括14名女性。最常见的表现包括腰痛（N = 15）和头痛（N = 10）。16个肿瘤发生在腰骶部，10个发生在斜坡。初始手术包括活检（N = 17）、次全切除（N = 4）和大体全切除（N = 5）。每10个高倍视野的单个最高有丝分裂计数范围为0至6（平均值，1）。在7个肿瘤中发现了明显的核多形性。在两个肿瘤中观察到明显的细胞增生。在7个肿瘤中发现局灶性坏死。22例肿瘤的MIB-1标记指数（LI）为0 ~ 3.8（平均0.5）。Cyclin D1 LI范围为0 ~ 82.4（平均35.6）。7例p53免疫组化染色阳性，3例bcl-2抗体灶性阳性。5例肿瘤局部复发; 2例患者发生转移性疾病。13例患者接受了辅助化疗和/或放疗。在最后一次已知随访时，7例患者死于肿瘤（12至132个月随访）。另外5例患者死亡，2例在36个月和72个月随访时无肿瘤，3例患者死亡时肿瘤状态未知。7名患者仍活着，但有肿瘤证据（1至120个月），5名患者仍活着，但没有肿瘤证据（12至84个月）。1例患者未进行临床随访。总之，低MIB-1 LI和缺乏p53和bcl-2染色与大多数脊索瘤的低级别性质一致。高细胞周期蛋白D1 LI可能反映了细胞周期蛋白D1蛋白积累的趋势;然而，在这些肿瘤中，细胞周期蛋白D1对细胞增殖的影响似乎存在阻滞。细胞周期蛋白D1，MIB-1，p53和bcl-2免疫染色并没有出现提高一个人的能力，预测行为与常规光学显微镜。
Few studies have examined the role of cell proliferation and apoptotic markers in chordomas. This study retrospectively reviews the clinicopathologic features of 26 chordomas and examines MIB-1, p53, bcl-2, and cyclin D1 immunoreactivity in these neoplasms. Patients ranged in age from 34 to 78 years (mean, 60.7 years) and included 14 females. The most common presentations included lower back pain (N = 15) and headaches (N = 10). Sixteen tumors arose in the lumbosacral region and 10 in the clivus. Initial surgery included biopsy (N = 17), subtotal resection (N = 4), and gross total resection (N = 5). The single highest mitosis count per 10 high power fields ranged from 0 to 6 (mean, 1). Marked nuclear pleomorphism was identified in seven tumors. Marked hypercellularity was seen in two tumors. Focal necrosis was identified in seven tumors. MIB-1 labeling indices (LI) in 22 tumors ranged from 0 to 3.8 (mean, 0.5). Cyclin D1 LI ranged from 0 to 82.4 (mean, 35.6). Seven tumors had positive p53 immunostaining and three demonstrated focal positive staining with bcl-2 antibody. Five tumors locally recurred; two patients developed metastatic disease. Thirteen patients received adjuvant chemotherapy and/or radiation therapy. At last known follow-up, seven patients died with tumor (12 to 132 months follow-up). Five additional patients died, two without tumor at 36 and 72 months follow-up and three patients in whom the tumor status at death was not known. Seven patients were alive with evidence of tumor (1 to 120 months) and five patients were alive without evidence of tumor (12 to 84 months). Clinical follow-up was not available in one patient. In conclusion, the low MIB-1 LIs and the lack of p53 and bcl-2 staining is in keeping with the low-grade nature of most chordomas. High cyclin D1 LIs may be reflective of a tendency to accumulate cyclin D1 protein; however, there appears to be a block in the effect of cyclin D1 on cell proliferation in these tumors. Cyclin D1, MIB-1, p53, and bcl-2 immunostaining does not appear to improve one's ability to predict behavior versus routine light microscopy.
影响因子：
10.5
作者：
MARTINEZ, J;GEORGOFF, I;LEVINE, AJ
通讯作者：
LEVINE, AJ