[Analysis of dysarthria in amyotrophic lateral sclerosis--MRI of the tongue and formant analysis of vowels].
[Analysis of dysarthria in amyotrophic lateral sclerosis--MRI of the tongue and formant analysis of vowels].
复制标题
DOI：
--
复制
发表时间：
1994-03
期刊：
影响因子：
--
通讯作者：
S. Watanabe;K. Arasaki;H. Nagata;S. Shouji
中科院分区：
文献类型：
--
作者：
S. Watanabe;K. Arasaki;H. Nagata;S. Shouji
为了评估ALS患者的构音障碍，我们使用MRI（梯度重相回波法），并将其与计算机声学分析进行比较。要求5名进行性球麻痹型ALS男性患者和5名正常男性发出5个日语元音/a/。i. u/./ e/。o/.通过梯度重相回波法（0.2特斯拉，TR：30 ms，TE：10 ms，FA 25 ℃，Hitachi）获得矢状舌和声道的MRI。我们可以清楚地看到每个元音发音时舌形的变化和声道狭窄的部位。在正常受试者中，舌形和声道的狭窄部位在每个元音之间是可区分的，但在ALS中不清楚。声学分析表明，第一共振峰频率/i/./ u/的第二共振峰频率高于正常人，/i/的第二共振峰频率高于正常人。ALS患者e/明显低于正常人。ALS患者各元音第一、第二、第三共振峰频率与正常值的差异以/i/最为明显。e/.据推测，/i/和/e/是ALS中最受干扰的元音。元音的第一共振峰频率和第二共振峰频率取决于舌形和口腔宽度。因此，ALS患者的声学分析结果表明，舌在/i/中的运动较差。u/./ e/和与矢状舌MRI的结果一致。梯度重相回波MRI舌矢状面和声学分析对ALS构音障碍的评价有一定的价值。
To evaluate dysarthria in patients with ALS, we used MRI (gradient rephasing echo method) and compared it with the computed acoustic analysis. Five ALS male patients of progressive bulbar palsy type and five normal male were asked to phonate the five Japanese vowels, /a/./i/./u/./e/./o/. MRI of the sagittal tongue and vocal tract was obtained by the gradient rephasing echo method (0.2 Tesla, TR:30 ms, TE:10 ms, FA 25 degrees C, Hitachi). We could clearly visualize the change of tongue shape and the narrow site of the vocal tract for each vowel phonation. In normal subjects, the tongue shape and the narrow site of the vocal tract were distinguishable between each vowel, but unclear in ALS. Acoustic analysis showed that the first formant frequency of /i/./u/ in ALS was higher than normal and the second formant frequency of /i/./e/ in ALS was significantly lower than normal. The discrepancy from the normal first, second and third formant frequency for each vowel of ALS was most seen in /i/./e/. It was speculated that /i/ and /e/ were the most disturbed vowels in ALS. The first and second formant frequency of vowel depends on the tongue shape and the width of the oral cavity. Therefore the results of the acoustic analysis in ALS indicated poor movement of tongue in /i/./u/./e/ and were compatible with the findings of the sagittal tongue MRI. The sagittal view of the tongue in the gradient rephasing echo MRI and the acoustic analysis are useful in evaluation dysarthria in ALS.