Percentage of future liver remnant volume before portal vein embolization influences the degree of liver regeneration after hepatectomy. J Gastrointest Surg
Percentage of future liver remnant volume before portal vein embolization influences the degree of liver regeneration after hepatectomy. J Gastrointest Surg
复制标题
门静脉栓塞前未来肝脏残余体积的百分比影响肝切除后肝脏再生的程度。
DOI：
10.1007/s11605-013-2237-y
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发表时间：
2013
影响因子：
3.2
通讯作者：
Baba H.
中科院分区：
文献类型：
--
作者：
Okabe H;Beppu T;Nakagawa S;Yoshida M;Hayashi H;Masuda T;Imai K;Mima K;Kuroki H;Nitta H;Hashimoto D;Chikamoto A;Ishiko T;Watanabe M;Yamashita Y;Baba H.
背景：门静脉栓塞（PVE）和肝切除术诱导肝再生的临床决定因素尚不清楚。本研究的目的是探讨如何发生肝再生PVE后，肝切除术，并确定哪些因素强烈促进肝regeneration. MethodsThirteen谁接受了术前PVE和主要肝切除术的患者参加了这项研究。将PVE前的未来肝脏残留体积百分比（%FLR-前）与PVE后的残留肝脏体积（%FLR-后-PVE）和肝切除术后第7天的残留肝脏体积（%FLR-后-HR）进行比较。通过Logistic回归分析研究了PVE和肝切除术诱导肝再生的临床指标。前FLR、PVE后FLR和HR后FLR分别为448、579和761 cm 3。% FLR-前体与PVE和肝切除诱导的肝再生显著相关（r= 0.63，p < 0.0001）。多元回归分析显示，只有%FLR-前与术后肝再生独立相关（p= 0.027，odds ratio = 13.8）。结论PVE术后及后续肝切除术后，肝再生分两步完成。肝再生受到%FLR前体的强烈影响。
BackgroundClinical determinants of liver regeneration induced by portal vein embolization (PVE) and hepatectomy remain unclear. The aims of this study were to investigate how liver regeneration occurs after PVE followed by hepatectomy and to determine which factors strongly promote liver regeneration.MethodsThirty-six patients who underwent both preoperative PVE and major hepatectomy were enrolled in this study. Percentage of future liver remnant volume before PVE (%FLR-pre) was compared with the remnant liver volume after PVE (%FLR-post-PVE) and on postoperative day 7 after hepatic resection (%FLR-post-HR). Clinical indicators contributing to liver regeneration induced by both PVE and hepatectomy were examined by logistic regression analysis.ResultsPVE and hepatectomy caused a two-step regeneration. FLR-pre, FLR-post-PVE, and FLR-post-HR were 448, 579, and 761 cm3, respectively. The %FLR-pre was significantly associated with liver regeneration induced by both PVE and hepatectomy (r= 0.63,p< 0.0001). Multiple regression analysis showed that only %FLR-pre was independently correlated with posthepatectomy liver regeneration (p= 0.027, odds ratio = 13.8).ConclusionAfter PVE and the subsequent hepatectomy, liver regeneration was accomplished in a two-step manner. Liver regeneration was strongly influenced by the %FLR-pre.