Prospective surveillance study of severe hyperbilirubinaemia in the newborn in the UK and Ireland
Prospective surveillance study of severe hyperbilirubinaemia in the newborn in the UK and Ireland
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DOI：
10.1136/adc.2006.105361
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发表时间：
2007-09-01
影响因子：
4.4
通讯作者：
Plait, Mary Jane
中科院分区：
文献类型：
--
作者：
Manning, Donal;Todd, Peter;Plait, Mary Jane
目的：确定新生儿严重高胆红素血症的发生率，并确定相关的临床和人口统计学变量以及短期结局。设计：前瞻性、基于人群的研究。地点：英国和爱尔兰共和国，2003年5月1日至2005年5月31日。参与者：出生后第一个月伴有严重高胆红素血症的婴儿（最大未结合血清胆红素>= 510 mu mol/l）。结果：108名婴儿符合病例定义，106名来自英国，2名来自爱尔兰共和国。英国严重高胆红素血症的发生率为7.1/10万活产（95% CI 5.8 - 8.6）。住院病例仅20例；88例入院时伴有严重黄疸。男性64例（60.4%），少数民族56例（51.8%）。87例（80.5%）为纯母乳喂养，合并症包括溶血、脱水、感染和瘀伤。14名婴儿表现出胆红素脑病的证据，其中3人死亡。在英国，胆红素脑病的发病率为每10万活产婴儿0.9例（95% CI 0.46 - 1.5）。结论：这是首个关于新生儿严重高胆红素血症发生率的大型、前瞻性、基于人群的研究。临床和人口关联以及确定的短期结果与最近在北美和欧洲报道的相同。
Objectives: To determine the incidence of severe hyperbilirubinaemia in the newborn, and to identify associated clinical and demographic variables, and short-term outcomes.Design: Prospective, population-based study.Setting: UK and Republic of Ireland, between 1 May 2003 and 31 May 2005.Participants: Infants in the first month of life with severe hyperbilirubinaemia (maximum unconjugated serum bilirubin >= 510 mu mol/l).Results: 108 infants met the case definition, 106 from the UK and 2 from the Republic of Ireland. The UK incidence of severe hyperbilirubinaemia was 7.1/100 000 live births (95% CI 5.8 to 8.6). Only 20 cases presented in hospital; 88 were admitted with severe jaundice. 64 (60.4%) cases were male, and 56 (51.8%), were of ethnic minority origin. 87 (80.5%) cases were exclusively breast fed. Co-morbidity included haemolysis, dehydration, infection and bruising. 14 infants showed evidence of bilirubin encephalopathy, of whom 3 died. The UK incidence of bilirubin encephalopathy was 0.9/100 000 live births (95% CI 0.46 to 1.5).Conclusions: This is the first large, prospective, population-based study of the incidence of severe hyperbilirubinaemia in the newborn. The clinical and demographic associations, and short-term outcomes identified, are the same as those reported recently in North America and Europe.