Pancreatic beta cell function in lean and obese Japanese with various degrees of glucose tolerance.
Pancreatic beta cell function in lean and obese Japanese with various degrees of glucose tolerance.
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DOI：
10.1507/endocrj.ej13-0046
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发表时间：
2013
影响因子：
2
通讯作者：
M. Takahara;N. Katakami;H. Kaneto;Midori Noguchi;I. Shimomura
中科院分区：
文献类型：
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作者：
M. Takahara;N. Katakami;H. Kaneto;Midori Noguchi;I. Shimomura
本研究的目的是调查日本人群中肥胖受试者与具有相同糖耐量的瘦受试者相比是否具有不同的胰岛素分泌能力。我们总共纳入了 1749 名日本员工，他们接受了 75 克口服葡萄糖耐量测试 (OGTT)。研究人群按120分钟血糖水平分为十分位数，并比较肥胖和非肥胖受试者（体重指数≥25 kg/m2）之间的胰岛素分泌指数和胰岛素敏感性指数。本研究中使用的指数为松田指数、胰岛素生成指数和处置指数。肥胖受试者的松田指数值显着低于非肥胖受试者，而胰岛素生成指数值则显着高于非肥胖受试者（均 p < 0.05）。当研究人群按腰围进行分类时，也观察到了类似的结果。总之，与具有相同负荷后葡萄糖水平的非肥胖日本受试者相比，来自 75 g OGTT 数据的处置指数在肥胖日本受试者中同样降低。未来的研究需要确认肥胖的日本受试者中葡萄糖不耐症的发生是否与非肥胖的日本受试者一样伴随着相同程度的胰腺β细胞功能障碍。
The aim of the current study was to investigate whether obese subjects have different insulin secretory capacity compared to lean subjects with the same glucose tolerance in a Japanese population. We included a total of 1749 Japanese employees who underwent 75-g oral glucose tolerance test (OGTT). The study population was divided into deciles of 120-min glucose levels and the indices of insulin secretion and insulin sensitivity in each decile were compared between the subjects with and without obesity (body mass index ≥ 25 kg/m2). The indices used in the current study were Matsuda index, insulinogenic index, and disposition index. Obese subjects had significantly lower values of Matsuda index and significantly higher value of insulinogenic index than non-obese subjects in every decile (all p 0.05). Similar findings were observed when the study population was classified by waist circumference. In conclusion, disposition index derived from the data of 75-g OGTT was similarly decreased in obese Japanese subjects compared to non-obese Japanese subjects with the same post-load glucose levels. Future studies will be needed to confirm whether the development of glucose intolerance in obese Japanese subjects is accompanied by the same degree of pancreatic beta cell dysfunction as non-obese Japanese subjects.