Two-component system YvqEC-dependent bacterial resistance against vancomycin in Bacillus thuringiensis
Two-component system YvqEC-dependent bacterial resistance against vancomycin in Bacillus thuringiensis
复制标题
苏云金芽孢杆菌双组分系统 YvqEC 依赖性细菌对万古霉素的耐药性
DOI：
10.1007/s10482-015-0489-0
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发表时间：
2015-05
影响因子：
2.6
通讯作者：
He, Jin
中科院分区：
文献类型：
--
作者：
Hu, Yimin;Fan, Qingyun;Wang, Xun;He, Jin
YvqEC is one of the two-component signal transduction systems that may respond to cell envelope stress and enable cells to adjust multiple cellular functions. It consists of a histidine kinase YvqE and a response regulator YvqC. In this study, we separately constructed a single gene mutant ΔyvqE and a double gene mutant ΔyvqEC in Bacillus thuringiensis BMB171 through a homing endonucleases I-SceI mediated markerless gene deletion method. We found that the deletion of either yvqE or yvqEC weakened the resistance of B. thuringiensis against vancomycin. We also identified nine operons that may be involved in the cellular metabolism regulated by YvqC. This study not only enriches our understanding of bacterial resistance mechanisms against vancomycin, but also helps investigate the functions of YvqEC.
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影响因子：
2.9
作者：
Johnson, James M.;Sanford, Brianne L.;Strom, Alexander M.;Tadayon, Stephanie N.;Lehman, Brent P.;Zirbes, Arrianna M.;Bhattacharyya, Sudeep;Musier-Forsyth, Karin;Hati, Sanchita
通讯作者：
Hati, Sanchita
影响因子：
4.4
作者：
Jieping Wang;H. Mei;Hongliang Qian;Qing Tang;Xiaocui Liu;Ziniu Yu;Jin He
通讯作者：
Jieping Wang;H. Mei;Hongliang Qian;Qing Tang;Xiaocui Liu;Ziniu Yu;Jin He
影响因子：
3.6
作者：
Mascher, T;Margulis, NG;Helmann, JD
通讯作者：
Helmann, JD
影响因子：
2.8
作者：
Fritsch, Frederike;Mauder, Norman;Beier, Dagmar
通讯作者：
Beier, Dagmar
影响因子：
3.2
作者：
Jordan, Sina;Junker, Anja;Mascher, Thorsten
通讯作者：
Mascher, Thorsten