Challenges for biomarkers in cancer detection
Challenges for biomarkers in cancer detection
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DOI：
10.1196/annals.1318.003
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Srivastava, S
中科院分区：
文献类型：
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作者：
Wagner, PD;Verma, M;Srivastava, S
癌症仍然是美国的主要死亡原因。生物标志物可用于检测不同阶段、起始、发展和进展的癌症。生物标志物的期望性质和效用在于其提供疾病进展的早期指示的能力。生物标志物应易于检测，可在人群中测量，并可用于早期癌症检测，识别高风险个体，检测复发或监测干预研究中的终点。最近的技术进步有助于开发非侵入性，敏感和特异性的生物标志物，以在疾病的早期阶段检测癌症。
Cancer remains the leading cause of death in the United States. Biomarkers can be used to detect cancer in different stages, initiation, development, and progression. The desirable property and utility of a biomarker lie in its ability to provide an early indication of disease progression. Biomarkers should be easy to detect, measurable across populations, and useful for detection of cancer at an early stage, identification of high-risk individuals, detection of recurrence, or monitoring endpoints in intervention studies. Recent technological advances have helped develop noninvasive, sensitive, and specific biomarkers to detect cancer at early stages of the disease.