Hyaluronic Acid Stabilized Iodine-Containing Nanoparticles with Au Nanoshell Coating for X-ray CT Imaging and Photothermal Therapy of Tumors
Hyaluronic Acid Stabilized Iodine-Containing Nanoparticles with Au Nanoshell Coating for X-ray CT Imaging and Photothermal Therapy of Tumors
复制标题
具有金纳米壳涂层的透明质酸稳定的含碘纳米粒子用于肿瘤的 X 射线 CT 成像和光热治疗
DOI：
10.1021/acsami.6b11918
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发表时间：
2016-10-19
影响因子：
9.5
通讯作者：
Yang, Xiaoying
中科院分区：
文献类型：
--
作者：
Liu, Xinghua;Gao, Chunhui;Yang, Xiaoying
近年来，人们在开发具有诊断和治疗功能的多功能纳米颗粒方面做了大量的工作。为了增强肿瘤的CT成像和光热治疗，我们以碘化纳米颗粒为模板构建了金纳米壳结构，并展示了一种简单而有效的方法，通过在碘化纳米颗粒表面涂覆金纳米壳，然后用透明质酸对其表面进行修饰，合成了生物相容性和分散良好的多功能纳米颗粒。所制得的聚（2-甲基丙烯酸基（3-酰胺-2,4,6-三碘苯甲酸））/聚乙烯亚胺/金纳米壳/透明质酸（PMATIB/PEI/金纳米壳/HA）纳米粒子具有较高的x射线衰减系数和光热效率。经MCF-7荷瘤小鼠静脉注射后，PMATIB/PEI/Au纳米壳/HA纳米颗粒在肿瘤内有效积累，显著增强肿瘤CT成像，并在近红外照射下通过对病灶的热治疗选择性消融肿瘤。因此，PMATIB/PEI/Au纳米壳/HA纳米颗粒在CT诊断和CT引导的聚焦光热肿瘤治疗中显示出巨大的潜力。
In recent years, considerable efforts have been made for the development of multifunctional nanoparticles with diagnosis and therapy functions. To achieve enhanced CT imaging and photothermal therapy on the tumor, we employed iodinated nanoparticles as template to construct Au nanoshell structure and demonstrated a facile but effective approach to synthesize biocompatible and well-dispersed multifunctional nanoparticles by coating iodinated nanoparticles with Au nanoshell and subsequent surface modification by hyaluronic acid. The resultant poly(2-methacryl(3-amide-2,4,6-triiodobenzoic acid))/polyethylenimine/Au nanoshell/hyaluronic acid (PMATIB/PEI/Au nanoshell/HA) nanoparticles had relatively high X-ray attenuation coefficient and photothermal efficiency. After intravenous injection into MCF-7 tumor-bearing mice, PMATIB/PEI/Au nanoshell/HA nanoparticles were efficiently accumulated in the tumor, remarkably enhanced the tumor CT imaging, and selectively ablated the tumor through the thermal treatment of lesions under the NIR irradiation. Thus, PMATIB/PEI/Au nanoshell/HA nanoparticles displayed a great potential for CT diagnosis and CT-guided, focused photothermal tumor therapy.