Neuropsychological abnormalities in patients with dementia in CRF 01_AE HIV-1 infection
Neuropsychological abnormalities in patients with dementia in CRF 01_AE HIV-1 infection
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DOI：
10.1212/01.wnl.0000253196.78193.c7
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发表时间：
2007-02-13
期刊：
影响因子：
9.9
通讯作者：
Shikuma, C. M.
中科院分区：
文献类型：
--
作者：
Valcour, V. G.;Sithinamsuwan, P.;Shikuma, C. M.
在循环重组型（CRF）01_AE HIV-1患者中，HIV相关性痴呆（HAD）尚未确定。在这项研究中，我们比较了15名泰国人与HAD，15名泰国人没有HAD，和30名HIV阴性对照组的神经心理学表现。HIV-1参与者从未接受过高活性抗逆转录病毒治疗，并且与年龄、教育程度和CD 4计数相匹配。在HAD与HIV阴性受试者的大多数认知领域中发现了神经心理学测试异常，证实了CRF01_AE中存在HAD。
HIV-associated dementia (HAD) is not firmly established in patients with circulating recombinant form (CRF) 01_AE HIV-1. In this study, we compared neuropsychological performance among 15 Thai individuals with HAD, 15 Thai individuals without HAD, and 30 HIV-negative control subjects. HIV-1 participants were highly active anti-retroviral therapy naive and matched by age, education, and CD4 count. Neuropsychological testing abnormalities were identified in most cognitive domains among HAD vs HIV-negative participants, confirming the presence of HAD in CRF01_AE.