Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia
Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia
复制标题
DOI：
10.1016/s0893-133x(00)00121-4
复制
发表时间：
2000-10-01
影响因子：
7.6
通讯作者：
Leonard, S
中科院分区：
文献类型：
--
作者：
Breese, CR;Lee, MJ;Leonard, S
以往的研究表明，神经元烟碱乙酰胆碱受体的表达或功能异常可能参与精神分裂症的神经病理生理。[H-3]-尼古丁和[H-3]-地棘蛙素结合进行了比较，在死后的大脑从控制和精神分裂症受试者不同的吸烟史。在对照组中，随着烟草使用的增加，海马体、皮质和尾状核中的受体结合增加。相比之下，精神分裂症吸烟者与对照组吸烟者相比，这些大脑区域的烟碱受体水平降低。在大鼠中，长期氟哌啶醇和尼古丁处理用于评估尼古丁对受体上调的神经抑制作用。尼古丁治疗以及氟哌啶醇和尼古丁共同治疗的动物中均观察到皮质烟碱受体显著增加，这表明尼古丁使用后精神分裂症患者高亲和力神经元烟碱受体的异常调节与慢性抗精神病药物治疗无关。(C)2000年美国神经精神药理学学会。出版社：Elsevier Science Inc.
Previous studies have suggested that an abnormality in neuronal nicotinic acetylcholine receptor expression or function may be involved in the neuropathophysiology of schizophrenia. [H-3]-nicotine and [H-3]-epibatidine binding were compared in postmortem brain from control and schizophrenic subjects with varying smoking histories. In control subjects, increased receptor binding was seen in hippocampus, cortex, and caudate with increasing tobacco use. In contrast, schizophrenic smokers had reduced nicotinic receptor levels in these brain regions compared to control smokers. Chronic haloperidol and nicotine treatment, in the rat, was used to assess neuroleptic effects on receptor up-regulation by nicotine. A significant increase in cortical nicotinic receptors was seen in both nicotine treated as well as haloperidol and nicotine co-treated animals, suggesting that the abnormal regulation of high affinity neuronal nicotinic receptors in schizophrenics following nicotine use was not related to chronic neuroleptic treatment. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.