Myocardial salvage after intracoronary thrombolysis with streptokinase in acute myocardial infarction.
Myocardial salvage after intracoronary thrombolysis with streptokinase in acute myocardial infarction.
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急性心肌梗死冠状动脉内溶栓后链激酶的心肌挽救。
DOI：
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发表时间：
1981
影响因子：
158.5
通讯作者：
E. Braunwald
中科院分区：
文献类型：
--
作者：
J. Markis;M. Malagold;J. Parker;K. Silverman;W. Barry;A. Als;S. Paulin;W. Grossman;E. Braunwald
9例急性心肌梗死患者在症状发作后2.3至4.3小时（平均3.5小时）进行了心导管插入术和冠状动脉内链激酶输注。在所有患者中，闭塞的冠状动脉在约20分钟内被打开，但在1例患者中发生再闭塞。冠状动脉内注射铊-201评估溶栓对心肌挽救的即时效果。在9例患者中的7例中观察到局部灌注改善，表明再通后心肌挽救。一名患者在一周前也发生了非透壁性梗死，溶栓后无变化。在第九例患者中，冠状动脉再通后出现再闭塞和心肌灌注缺损恶化。与溶栓后1.5小时进行的冠状动脉内扫描相比，2例患者链激酶输注后2周和3个月进行的冠状动脉内铊-201研究没有变化。这些短期观察结果表明，冠状动脉内溶栓后再通阻塞的冠状动脉可以挽救受损的心肌，但是，评价这种程序对生存率和心肌功能的长期影响需要对照临床试验。
Nine patients with acute myocardial infarction had cardiac catheterization and intracoronary infusions of streptokinase 2.3 to 4.3 hours (mean, 3.5) after the onset of symptoms. Occluded coronary arteries were opened within approximately 20 minutes in all patients, but reocclusion occurred in one patient. The immediate effect of thrombolysis on myocardial salvage was assessed with the intracoronary injection of thallium-201. Improved regional perfusion, indicating myocardial salvage after recanalization, was observed in seven of the nine patients. One patient, who had also sustained a nontransmural infarction one week before, had no change after thrombolysis. In the ninth patient, recanalization of a coronary artery was followed by reocclusion and worsening of the myocardial-perfusion defect. Intracoronary thallium-201 studies two weeks and three months after streptokinase infusion in two patients were unchanged in comparison with scintiscans performed 1.5 hours after thrombolysis. These short-term observations suggest that recanalization of obstructed coronary arteries after intracoronary thrombolysis can salvage jeopardized myocardium, However, evaluation of the long-term effects of this procedure on survival and myocardial function will require controlled clinical trials.
演变中的心肌梗塞的冠状动脉内溶栓。
影响因子：
39.2
作者：
Ganz,W
通讯作者：
Ganz,W