On a kinetic origin of heredity: Minority control in a replicating system with mutually catalytic molecules
On a kinetic origin of heredity: Minority control in a replicating system with mutually catalytic molecules
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DOI：
10.1006/jtbi.2001.2481
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发表时间：
2002-02-21
影响因子：
2
通讯作者：
Yomo, T
中科院分区：
文献类型：
--
作者：
Kaneko, K;Yomo, T
作为研究遗传信息起源的第一站，我们研究了某些分子如何保存在细胞世代上，并在控制细胞的生长中起重要作用。我们考虑了一个由原始细胞组成的模型。每个原始细胞都包含两个相互催化的分子物种（x和y），每种分子物种具有催化活性和不活跃的类型。假定y的一种物种的合成速度较慢。通过原始细胞的划分，系统可以通过选择非常罕见的波动，在大多数原始细胞中只有少数活性y，几乎没有活性的y分子。在这种状态下，活跃的Y分子被证明可以控制原核的行为。少数分子物种作为遗传的载体，由于其人口的相对离散的性质，与大多数物种相比，这些物种在统计上符合大量法则。少数族裔控制状态可能会给确保少数分子传播的机制带来选择压力。一旦这些机制到位，少数分子就会成为跨几代信息传输信息的理想存储装置，从而产生“遗传信息”。还讨论了这种少数群体控制状态与可发展性的相关性。
As the first stop in an investigation of the origin of genetic information, we study how some species of molecules arc preserved over cell generations and play an important role in controlling the growth of a cell. We consider a model consisting of protocells. Each protocell contains two mutually catalysing molecule species (X and Y), each of which has catalytically active and inactive types. One of the species Y is assumed to have a slower synthesis speed. Through divisions of the protocells, the system reaches and remains in a state in which there are only a few active Y and almost no inactive Y molecules in most protocells, through the selection of very rare fluctuations. In this state, the active Y molecules are shown to control the behavior of the protocell. The minority molecule species act as the carrier of heredity, due to the relatively discrete nature of its population, in comparison with the majority species which behaves statistically in accordance with the law of large numbers. The minority controlled state may give rise to a selection pressure for mechanisms that ensure the transmission of the minority molecule. Once those mechanisms are in place, the minority molecule becomes the ideal storage device for information to be transmitted across generations, thus giving rise to "genetic information". The relevance of this minority controlled state to evolvability is also discussed.