Effects of neurotensin in amygdaloid spatial learning mechanisms
Effects of neurotensin in amygdaloid spatial learning mechanisms
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DOI：
10.1016/j.bbr.2010.02.038
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发表时间：
2010-07-11
影响因子：
2.7
通讯作者：
Lenard, Laszlo
中科院分区：
文献类型：
--
作者：
Laszlo, Kristof;Toth, Krisztian;Lenard, Laszlo
神经降压素(NT)作为一种神经递质和/或神经调节剂，在学习和奖赏相关过程中发挥作用。杏仁核中央核(CEA)参与记忆和学习机制的调节。在Morris水迷宫实验中，大鼠微量注射NT或神经降压素受体1拮抗剂SR 48692(ANT)。NT可显著缩短小鼠的逃避潜伏期。NT的作用可被ANT预处理所阻断。我们的结果表明，在大鼠中，CEA-NT促进了空间学习。我们澄清说，NTS1参与了这一行动。(C)2010爱思唯尔B.V.保留所有权利。
Neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reward related processes. The central nucleus of amygdala (CeA) participates in the regulation of memory and learning mechanisms. In Morris water maze test, rats were microinjected with NT or neurotensin receptor-1 (NTS1) antagonist SR 48692 (ANT). NT significantly reduced the escape latency. Effect of NT was blocked by ANT pretreatment. Our results show that in the rat CeA NT facilitates spatial learning. We clarified that NTS1s are involved in this action. (C) 2010 Elsevier B.V. All rights reserved.