Estimating the distribution of fitness effects from DNA sequence data: Implications for the molecular clock
Estimating the distribution of fitness effects from DNA sequence data: Implications for the molecular clock
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DOI：
10.1073/pnas.1833064100
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发表时间：
2003-09-02
影响因子：
11.1
通讯作者：
Eyre-Walker, A
中科院分区：
文献类型：
--
作者：
Piganeau, G;Eyre-Walker, A
我们提出了一种方法，用于估计新氨基酸突变的适应度效应分布，当这些突变可以被假定为稍微有利、稍微有害或强烈有害时。我们将该方法应用于来自几个不同物种的线粒体数据。在大多数数据集中，分布形状近似指数。我们的结果提供了对弱选择突变的适应度效应分布的估计，并为为什么分子钟在分类群和时间上相当恒定提供了可能的解释。
We present a method for estimating the distribution of fitness effects of new amino acid mutations when those mutations can be assumed to be slightly advantageous, slightly deleterious, or strongly deleterious. We apply the method to mitochondrial data from several different species. In the majority of the data sets, the shape of the distribution is approximately exponential. Our results provide an estimate of the distribution of fitness effects of weakly selected mutations and provide a possible explanation for why the molecular clock is fairly constant across taxa and time.