COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study
COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study
复制标题
DOI：
10.1016/s2352-4642(20)30177-2
复制
发表时间：
2020-09-01
影响因子：
36.4
通讯作者：
Tebruegge, Marc
中科院分区：
文献类型：
--
作者：
Goetzinger, Florian;Santiago-Garcia, Begona;Tebruegge, Marc
背景迄今为止，关于儿科COVID-19的数据很少，大多数报告来自中国。本研究旨在获取严重急性呼吸综合征冠状病毒2型儿童和青少年的关键数据方法这项多中心队列研究涉及25个欧洲国家的82个参与卫生保健机构，利用一个完善的研究网络-儿科结核病网络欧洲试验组（ptbnet）-该网络主要由儿科传染病专家和儿科肺病专家组成。我们纳入了2020年4月1日至4月24日欧洲COVID-19大流行最初高峰期间通过RT-PCR在任何解剖部位检测到的所有18岁或以下确诊SARS-CoV-2感染的个体。我们使用单变量分析探索了与需要重症监护病房（ICU）住院和开始COVID-19药物治疗相关的因素，并应用多变量logistic回归和向后逐步分析进一步探索与ICU住院显著相关的因素。结果582例PCR证实的SARS-CoV-2感染者被纳入，中位年龄为5.0岁（IQR 0.5-12.0），男女性别比为1.15：1。145人（25%）有既往病史。363人（62%）入院治疗。48例（8%）患者需要入住ICU，25例（4%）患者需要机械通气（中位持续时间7天，IQR 2-11，范围1-34），19例（3%）患者需要强心剂支持，1例（
Background To date, few data on paediatric COVID-19 have been published, and most reports originate from China. This study aimed to capture key data on children and adolescents with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across Europe to inform physicians and health-care service planning during the ongoing pandemic.Methods This multicentre cohort study involved 82 participating health-care institutions across 25 European countries, using a well established research network-the Paediatric Tuberculosis Network European Trials Group (ptbnet)-that mainly comprises paediatric infectious diseases specialists and paediatric pulmonologists. We included all individuals aged 18 years or younger with confirmed SARS-CoV-2 infection, detected at any anatomical site by RT-PCR, between April 1 and April 24, 2020, during the initial peak of the European COVID-19 pandemic. We explored factors associated with need for intensive care unit (ICU) admission and initiation of drug treatment for COVID-19 using univariable analysis, and applied multivariable logistic regression with backwards stepwise analysis to further explore those factors significantly associated with ICU admission.Findings 582 individuals with PCR-confirmed SARS-CoV-2 infection were included, with a median age of 5.0 years (IQR 0.5-12.0) and a sex ratio of 1.15 males per female. 145 (25%) had pre-existing medical conditions. 363 (62%) individuals were admitted to hospital. 48 (8%) individuals required ICU admission, 25 (4%) mechanical ventilation (median duration 7 days, IQR 2-11, range 1-34), 19 (3%) inotropic support, and one (