ROLE OF SEPTAL VASOPRESSIN INNERVATION IN PATERNAL BEHAVIOR IN PRAIRIE VOLES (MICROTUS-OCHROGASTER)
ROLE OF SEPTAL VASOPRESSIN INNERVATION IN PATERNAL BEHAVIOR IN PRAIRIE VOLES (MICROTUS-OCHROGASTER)
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DOI：
10.1073/pnas.91.1.400
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发表时间：
1994-01-04
影响因子：
11.1
通讯作者：
DEVRIES, GJ
中科院分区：
文献类型：
--
作者：
WANG, ZX;FERRIS, CF;DEVRIES, GJ
雄性草原田鼠与雌性配对后，其社会行为发生了重大变化，其中之一是父性反应增强。这些变化是伴随着波动的[Arg 8]加压素免疫反应（AVP-IR）纤维的密度在侧隔，表明隔AVP可能参与这些变化。为了探讨间隔AVP可能参与父亲的反应，我们测试了是否注射生理盐水，AVP，或VI。将受体拮抗剂[1-（β-巯基-β，β-环戊亚甲基丙酸），2-（O-甲基酪氨酸）]AVP [d（CH 2）5 Tyr（Me）AVP]注入侧隔，影响雄性草原田鼠表现出的四种最显著的父性活动：梳理、蹲伏、接触和取回幼仔。在第一个实验中，性经验不足的男性接受了单次注射的AVP，生理盐水，或d（CH 2）5 Tyr（Me）AVP在侧隔，之后，他们的父亲的反应记录在10分钟的时间。注射AVP的动物花了更多的时间接触和蹲伏在幼崽，而d（CH 2）5 Tyr（Me）AVP注射的动物花了更少的时间梳理幼崽比盐水注射的动物。在后续研究中，一组动物接受AVP注射，然后向外侧隔中注射盐水或d（CH 2）5 Tyr（Me）-AVP）。第二组动物接受盐水注射，然后将盐水或d（CH 2）5 Tyr（Me）AVP注射到外侧隔中。在这两个组中，动物花更少的时间梳理，蹲下，并接触幼崽，如果他们第一次注射d（CH 2）5 Tyr（Me）AVP。对照实验表明，AVP对父体反应性的影响具有剂量和部位特异性。这些数据表明，隔AVP通过V1 a受体介导的机制增强父亲的反应性。
After being paired with females, male prairie voles show major changes in their social behaviors among which is an increase in paternal responsiveness. These changes are accompanied by fluctuations in the density of the [Arg8]vasopressin-immunoreactive (AVP-ir) fibers in the lateral septum, suggesting that septal AVP might be involved in these changes. To explore a possible involvement of septal AVP in paternal responsiveness, we tested whether injections of saline, AVP, or the VI. receptor antagonist [1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid),2-(O-methyltyrosine]AVP [d(CH2)5Tyr(Me)AVP] into the lateral septum influenced the four most prominent paternal activities displayed by male prairie voles; grooming, crouching over, contacting, and retrieving pups. In a first experiment, sexually inexperienced males received a single injection of AVP, saline, or d(CH2)5Tyr(Me)AVP in the lateral septum, after which their paternal responsiveness was recorded during a 10-min period. AVP-injected animals spent more time contacting and crouching over pups, while d(CH2)5Tyr(Me)AVP-injected animals spent less time grooming pups than saline-injected animals. In a follow-up study, one group of animals received an injection of AVP preceded by an injection of saline or d(CH2)5Tyr(Me)-AVP) Into the lateral septum. A second group of animaLs received an injection of saline preceded by an injection of saline or d(CH2)5Tyr(Me)AVP into the lateral septum. In both groups, animals spent less time grooming, crouching over, and contacting pups if they had first been injected with d(CH2)5Tyr(Me)AVP. Control experiments suggested that the effects of AVP on paternal responsiveness were dose- and site-specific. These data suggest that septal AVP enhances paternal responsiveness by a V1a receptor-mediated mechanism.