Proteinaceous cysteine protease inhibitors.
Proteinaceous cysteine protease inhibitors.
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DOI：
10.1007/s00018-004-4445-9
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发表时间：
2005-03
期刊：
影响因子：
--
通讯作者：
Dubin G
中科院分区：
文献类型：
--
作者：
Dubin G
蛋白质半胱氨酸蛋白酶抑制剂的研究起源于 20 世纪 60 年代半胱氨酸蛋白酶抑制剂的发现。从那时起，人们发现了一个丰富而迷人的蛋白质世界，这些蛋白质控制和调节许多重要的生理过程，从蛋白质周转的基础知识到发育和大脑功能。如此重要且复杂的系统出现故障不可避免地会导致病变。许多威胁疾病，例如癌症或神经系统疾病，仅举一些，归因于蛋白酶抑制剂平衡的失调。此外，感染病理学和宿主防御的重要方面依赖于蛋白水解和蛋白酶抑制。蛋白酶抑制剂领域的最新进展引起了人们对利用所收集的知识来控制相关病理过程的可能性的关注。本综述试图通过概述当前知识，让读者熟悉蛋白质半胱氨酸蛋白酶抑制剂。这项工作主要强调了抑制剂参与的生物过程，并重点关注异常蛋白酶-抑制剂平衡引起的病理学，指出了纠正它们的新可能性。
Studies of proteinaceous cysteine protease inhibitors originated with the discovery of cystatins in the 1960s. Since that time, a rich and fascinating world of proteins that control and regulate a multitude of important physiological processes, ranging from the basics of protein turnover to development and brain function, has been uncovered. Failures in such important and complex systems inevitably lead to pathologies. Many threatening diseases such as cancer or neurological disorders, to mention only some, are attributed to deregulation of proteaseinhibitor balance. Moreover, important aspects of infection pathology and host defense rely on proteolysis and protease inhibition. Recent advances in the field of protease inhibitors have drawn attention to the possible use of this collected knowledge to control related pathological processes. This review attempts to familiarize the reader with proteinaceous cysteine protease inhibitors by providing an overview of current knowledge. The work primarily highlights biological processes in which the inhibitors are involved and focuses on pathologies resulting from aberrant protease-inhibitor balance, pointing out emerging possibilities for their correction.
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