P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues
P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues
复制标题
DOI：
10.1038/385081a0
复制
发表时间：
1997-01-02
期刊：
影响因子：
64.8
通讯作者：
Hamann, A
中科院分区：
文献类型：
--
作者：
Austrup, F;Vestweber, D;Hamann, A
当被激活时，T辅助细胞分化成两个亚群之一，Th 1和Th 2，其特征在于细胞因子产生的不同概况。Th 1细胞激活参与保护和自身免疫的促炎效应机制，而Th 2细胞诱导体液和过敏反应并下调局部炎症（1，2）。除了细胞因子库的差异之外，没有建立区分两个子集的表型属性。在这里，我们表明，Th 1细胞，而不是Th 2细胞，能够结合P-选择素和E-选择素。此外，在Th 1为主的模型中，只有Th 1细胞可以有效地进入发炎部位，如致敏皮肤或关节炎关节，但在Th 2为主的过敏反应中不能。Th 1细胞向发炎皮肤中的迁移可以被针对P-和E-选择素的抗体阻断。这些结果为区分两种T辅助细胞亚群并介导其差异运输的粘附机制提供了证据，他们表明，选择性募集是效应器功能概况和局部免疫反应特征的额外调节水平。
WHEN activated, T helper cells differentiate into one of two subsets, Th1 and Th2, characterized by distinct profiles of cytokine production. Th1 cells activate pro-inflammatory effector mechanisms involved in protection and autoimmunity, whereas Th2 cells induce humoral and allergic responses and downregulate local inflammation(1,2). Apart from differences in the repertoire of cytokines, no phenotypic attributes are established that distinguish the two subsets. Here we show that Th1 cells, but not Th2 cells, are able to bind to P-selectin and E-selectin. Moreover, only Th1 cells can efficiently enter inflamed sites in Th1-dominated models, such as sensitized skin or arthritic joints, but not in a Th2-dominated allergic response, Immigration of Th1 cells into inflamed skin can be blocked by antibodies against P- and E-selectin, These results provide evidence for adhesion mechanisms to distinguish between the two T helper subsets and mediate their differential trafficking, They indicate that selective recruitment is an additional level of regulation for both effector function profile and character of a local immune response.