EFFECT OF MELATONIN ON THE FORCE OF SPONTANEOUS CONTRACTIONS OF INVITRO RAT SMALL AND LARGE-INTESTINE
EFFECT OF MELATONIN ON THE FORCE OF SPONTANEOUS CONTRACTIONS OF INVITRO RAT SMALL AND LARGE-INTESTINE
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DOI：
10.1111/j.1600-079x.1986.tb00750.x
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发表时间：
1986-01-01
影响因子：
10.3
通讯作者：
WEEKLEY, BL
中科院分区：
文献类型：
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作者：
HARLOW, HJ;WEEKLEY, BL
取大鼠不同部位的小肠和大肠，浸泡在泰德S液中，连接到力位移传感器上。褪黑素在不影响收缩频率的同时，使大鼠十二指肠和结肠段的自发收缩力量分别减少了92%和52%，相比之下，回肠和空肠的自发收缩力量分别只有25%和22%。对褪黑素反应最大的区域是那些先前研究表明含有最大浓度内源性褪黑素的区域。环鸟苷一磷酸，当在类似的制剂中测试时，不产生褪黑素的抑制反应特征。因此，据推测，这种激素在肠道内具有生理作用，包括运动；然而，正如其他研究人员所建议的那样，它的作用可能不是直接作用于平滑肌收缩，而是通过抑制5-羟色胺的收缩反应的间接作用。
Segments from various locations of the small and large intestine of the rat were removed, bathed in Tyrode''s solution and attached to a force displacement transducer. Melatonin, while not influencing the frequency of contraction, did reduce the force of spontaneous contractions of duodenal and colon segments of rat intestine by 92 and 52%, respectively compared to only 25 and 22% for the ileum and jejunum, respectively. Areas with greatest responsiveness to melatonin were those that previous studies have shown to contain the largest concentrations of endogenous melatonin. Cyclic guanosine monophosphate, when tested in similar preparations, did not produce an inhibitory response characteristic of melatonin. It is hypothesized, therefore, that this hormone has physiological action within the gut, including motility; however, its action may not be directly on smooth muscle contraction but may be through an indirect action inhibiting the contractile response of serotonin, as suggested by other investigators.