A review on Promising vaccine development progress for COVID-19 disease.
A review on Promising vaccine development progress for COVID-19 disease.
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DOI：
10.1016/j.vacun.2020.05.002
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发表时间：
2020-07-01
期刊：
影响因子：
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通讯作者：
Belete, Tafere Mulaw
中科院分区：
文献类型：
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作者：
Belete, Tafere Mulaw
引起2019年冠状病毒病的冠状病毒SARS-CoV-2(严重急性呼吸综合征冠状病毒2)株(新冠肺炎)的出现及其对全球的影响，在开发有效和安全的疫苗方面取得了势在必行的进展。尽管采取了几项措施，但该病毒的传播仍在继续。到目前为止，世界上发生了超过156万例病例和100万人死亡。已经努力开发针对MERS和SARS等人类冠状病毒(CoV)感染的疫苗。然而，目前还没有针对这些冠状病毒毒株的批准疫苗。在2003年大流行之后的几年里开发冠状病毒疫苗的这种先前的研究努力，为这位科学家为新冠肺炎设计新疫苗打开了大门。SARS-CoV和SARS-CoV-2具有高度的遗传相似性，并与相同的宿主细胞ACE2受体结合。通过使用不同的疫苗开发平台，包括全病毒疫苗、重组蛋白亚单位疫苗和核酸疫苗，几个候选疫苗在体外研究中显示了有效性，但很少进入临床试验。该综述简要介绍了SARS-CoV-2的一般特征，并讨论了针对新冠肺炎的疫苗开发工作中正在进行的进展。
The emergence of the strain of coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) that causes corona virus disease 2019 (COVID-19) and its impact on in the world have made imperative progress to develop an effective and safe vaccine. Despite several measures undertaken, the spread of this virus is ongoing. So far, more than 1,560,000 cases and 1000,000 deaths occurred in the world. Efforts have been made to develop vaccines against human coronavirus (CoV) infections such as MERS and SARS. However, currently, no approved vaccine exists for these coronavirus strains. Such Previous research efforts to develop a coronavirus vaccine in the years following the 2003 pandemic have opened the door for the scientist to design a new vaccine for the COVID-19. Both SARS-CoV and SARS-CoV-2 has a high degree of genetic similarity and bind to the same host cell ACE2 receptor. By using different vaccine development platforms including whole virus vaccines, recombinant protein subunit vaccines, and nucleic acid vaccines several candidates displayed efficacy in vitro studies but few progressed to clinical trials. This review provides a brief introduction of the general features of SARS-CoV-2 and discusses the current progress of ongoing advances in designing vaccine development efforts to counter COVID-19.