THE MINIMAL BRAIN DYSFUNCTION SYNDROME IN CHILDREN: I–THE SYNDROME AND ITS RELEVANCE FOE PSYCHIATRY II–A PSYCHOLOGICAL AND BIOCHEMICAL MODEL FOR THE SYNDROME
THE MINIMAL BRAIN DYSFUNCTION SYNDROME IN CHILDREN: I–THE SYNDROME AND ITS RELEVANCE FOE PSYCHIATRY II–A PSYCHOLOGICAL AND BIOCHEMICAL MODEL FOR THE SYNDROME
复制标题
儿童轻微脑功能障碍综合征：I——该综合征及其与精神病学的相关性 II——该综合征的心理和生物化学模型
DOI：
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发表时间：
1972
影响因子：
1.9
通讯作者：
P. Wender
中科院分区：
文献类型：
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作者：
P. Wender
轻微脑功能障碍（MBD）可能是潜伏期儿童中最常见的精神疾病。在过去，人们一直认为这种疾病是由脑损伤引起的，并且是自我限制的，在青春期就“长大”了。最近的证据审查表明，这些信念只有部分正确。首先，这种疾病显然也可以发生在遗传基础上;其次，MBD至少在某些情况下可以是几种形式的成人精神病理学的先驱。本文提出了MBD的遗传亚型是由单胺代谢紊乱引起的假说。有人提出，这种紊乱的新陈代谢导致某些基本的（“原发性”）心理功能障碍，这反过来又产生了观察到的（“继发性”）行为偏差。单胺代谢和假设的原发性功能障碍之间的关系的文献进行了审查。最后，对MBD的单胺假说提出了一些检验。
Minimal brain dysfunction (MBD) is probably the single most common psychiatric disorder seen in latency-age children. In the past it has been thought that the disorder was caused by brain damage and was self-limited, being “outgrown” at adolescence. Recent evidence is reviewed which suggests that these beliefs are only partly correct. First, the disorder can apparently also occcur on a genetic basis; second, MBD can, at least in some instances, be the forerunner of several forms of adult psychopathology. The paper advances the hypothesis that the genetic subgroup of MBD is caused by a disorder of monoamine metabolism. It is proposed that this disordered metabolism leads to certain basic (“primary”) psychological dysfunctions which in turn generate the observed (“secondary”) behavioral deviations. The literature dealing with the relationship between monoamine metabolism and the hypothesized primary dysfunctions is reviewed. Finally, some tests of the monoamine hypothesis of MBD are proposed.