Melatonin effect on daytime sleep in men: Suppression of EEG low frequency activity and enhancement of spindle frequency activity
Melatonin effect on daytime sleep in men: Suppression of EEG low frequency activity and enhancement of spindle frequency activity
复制标题
DOI：
10.1016/0304-3940(95)12118-n
复制
发表时间：
1995-12-01
影响因子：
2.5
通讯作者：
Borbely, AA
中科院分区：
文献类型：
--
作者：
Dijk, DJ;Roth, C;Borbely, AA
采用安慰剂对照交叉设计，研究了八名男性睡眠期间褪黑激素（5 毫克，口服）对脑电图 (EEG) 活动的影响。部分睡眠剥夺后，在白天睡眠之前（13-17 小时）立即服用褪黑激素。非快速眼动睡眠阶段和快速眼动睡眠持续时间没有受到显着影响。褪黑素增强非快速眼动睡眠中 13.75-14.0 Hz 频段（即在睡眠纺锤波频率范围内）的脑电图功率密度，并减少 15.25-16.5 Hz 频段的活动。在前 2 小时内，2.25-5.0 Hz 范围内的频谱值有所降低。脑电图的这些变化在某种程度上类似于苯二氮卓类安眠药引起的变化，以及夜间睡眠时内源性昼夜节律起搏器对睡眠脑电图频谱组成的贡献。
The effect of melatonin (5 mg, p.o.) on electroencephalographic (EEG) activity during sleep was investigated in eight men in a placebo-controlled cross-over design. Melatonin was administered immediately prior to a Ph daytime sleep episode (13-17 h) after a partial sleep deprivation. The non-REM sleep stages and REM sleep duration were not significantly affected. Melatonin enhanced EEG power density in non-REM sleep in the 13.75-14.0 Hz bin (i.e., within the frequency range of sleep spindles), and reduced activity in the 15.25-16.5 Hz band. In the first 2 h spectral values within the 2.25-5.0 Hz range were reduced. These changes in the EEG are to some extent similar to those induced by benzodiazepine hypnotics and to the contribution of the endogenous circadian pacemaker to the spectral composition of the sleep EEG when sleep occurs at night.